Refereed journal article or data article (A1)
The Association Between Grip Strength Measured in Childhood, Young- and Mid-adulthood and Prediabetes or Type 2 Diabetes in Mid-adulthood
List of Authors: Fraser Brooklyn J., Blizzard Leigh, Buscot Marie-Jeanne, Schmidt Michael D., Dwyer Terence, Venn Alison J., Magnussen Costan G.
Publisher: ADIS INT LTD
Publication year: 2021
Journal: Sports Medicine
Journal name in source: SPORTS MEDICINE
Journal acronym: SPORTS MED
Volume number: 51
Issue number: 1
Start page: 175
End page: 183
Number of pages: 9
ISSN: 0112-1642
eISSN: 1179-2035
DOI: http://dx.doi.org/10.1007/s40279-020-01328-2
URL: https://link.springer.com/article/10.1007/s40279-020-01328-2
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/50150179
Background
Although low child and adult grip strength is associated with adverse cardiometabolic health, how grip strength across the life course associates with type 2 diabetes is unknown. This study identified the relative contribution of grip strength measured at specific life stages (childhood, young adulthood, mid-adulthood) with prediabetes or type 2 diabetes in mid-adulthood.Methods
Between 1985 and 2019, 263 participants had their grip strength measured using an isometric dynamometer in childhood (9-15 years), young adulthood (28-36 years) and mid-adulthood (38-49 years). In mid-adulthood, a fasting blood sample was collected and tested for glucose and glycated haemoglobin (HbA1c). Participants were categorized as having prediabetes or type 2 diabetes if fasting glucose levels were >= 5.6 mmol or if HbA1c levels were >= 5.7% (>= 39 mmol/mol). A Bayesian relevant life course exposure model examined the association between lifelong grip strength and prediabetes or type 2 diabetes.Results
Grip strength at each time point was equally associated with prediabetes or type 2 diabetes in mid-adulthood (childhood: 37%, young adulthood: 36%, mid-adulthood: 28%). A one standard deviation increase in cumulative grip strength was associated with 34% reduced odds of prediabetes or type 2 diabetes in mid-adulthood (OR 0.66, 95% credible interval 0.40, 0.98).Conclusions
Greater grip strength across the life course could protect against the development of prediabetes and type 2 diabetes. Strategies aimed at increasing muscular strength in childhood and maintaining behaviours to improve strength into adulthood could improve future cardiometabolic health.
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