Refereed journal article or data article (A1)
The Association Between Grip Strength Measured in Childhood, Young- and Mid-adulthood and Prediabetes or Type 2 Diabetes in Mid-adulthood
List of Authors: Fraser Brooklyn J., Blizzard Leigh, Buscot Marie-Jeanne, Schmidt Michael D., Dwyer Terence, Venn Alison J., Magnussen Costan G.
Publisher: ADIS INT LTD
Publication year: 2021
Journal: Sports Medicine
Journal name in source: SPORTS MEDICINE
Journal acronym: SPORTS MED
Volume number: 51
Issue number: 1
Start page: 175
End page: 183
Number of pages: 9
ISSN: 0112-1642
eISSN: 1179-2035
DOI: http://dx.doi.org/10.1007/s40279-020-01328-2
URL: https://link.springer.com/article/10.1007/s40279-020-01328-2
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/50150179
Background
Although low child and adult grip strength is associated with adverse cardiometabolic health, how grip strength across the life course associates with type 2 diabetes is unknown. This study identified the relative contribution of grip strength measured at specific life stages (childhood, young adulthood, mid-adulthood) with prediabetes or type 2 diabetes in mid-adulthood.Methods
Between 1985 and 2019, 263 participants had their grip strength measured using an isometric dynamometer in childhood (9-15 years), young adulthood (28-36 years) and mid-adulthood (38-49 years). In mid-adulthood, a fasting blood sample was collected and tested for glucose and glycated haemoglobin (HbA1c). Participants were categorized as having prediabetes or type 2 diabetes if fasting glucose levels were >= 5.6 mmol or if HbA1c levels were >= 5.7% (>= 39 mmol/mol). A Bayesian relevant life course exposure model examined the association between lifelong grip strength and prediabetes or type 2 diabetes.Results
Grip strength at each time point was equally associated with prediabetes or type 2 diabetes in mid-adulthood (childhood: 37%, young adulthood: 36%, mid-adulthood: 28%). A one standard deviation increase in cumulative grip strength was associated with 34% reduced odds of prediabetes or type 2 diabetes in mid-adulthood (OR 0.66, 95% credible interval 0.40, 0.98).Conclusions
Greater grip strength across the life course could protect against the development of prediabetes and type 2 diabetes. Strategies aimed at increasing muscular strength in childhood and maintaining behaviours to improve strength into adulthood could improve future cardiometabolic health.
Downloadable publication This is an electronic reprint of the original article. |