B1 Vertaisarvioimaton kirjoitus tieteellisessä lehdessä
Balancing practicality and complexity in neuroimaging models of Parkinson's disease progression
Tekijät: Kaasinen, Valtteri; van Eimeren, Thilo
Kustantaja: NATURE PORTFOLIO
Julkaisuvuosi: 2025
Lehti: NPJ Parkinson's disease
Artikkelin numero: 262
Vuosikerta: 11
Numero: 1
eISSN: 2373-8057
DOI: https://doi.org/10.1038/s41531-025-01125-6
Julkaisun avoimuus kirjaamishetkellä: Avoimesti saatavilla
Julkaisukanavan avoimuus : Kokonaan avoin julkaisukanava
Verkko-osoite: https://www.nature.com/articles/s41531-025-01125-6
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/500427468
Reliable progression models are essential for clinical decision-making and trial design in Parkinson’s disease. We discuss linear, exponential, and sigmoidal patterns in PET and SPECT data, emphasizing the mismatch between biomarker and clinical trajectories. We propose more adaptable modeling strategies to improve patient stratification, support trial outcomes, and align imaging biomarkers with real-world disease complexity.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
Julkaisussa olevat rahoitustiedot:
V.K.: Advisory Boards (Abbvie, Nordic Infucare), Partnerships (Aqsens Health), Honoraria (Abbvie, Nordic Infucare, Lundbeck, Teva), Grants (the Finnish Parkinson Foundation, the Päivikki and Sakari Sohlberg Foundation, the Finnish Cultural Foundation, the Turku University Foundation, Turku University Hospital (VTR-funds). T.E.: Advisory Boards (ICON, Bial, Lundbeck Foundation), Honoraria (Eisai, International Society for Parkinson and Movement Disorders, Korean Movement Disorders Society), Consultancies (GT Gain Therapeutics SA, INSERM), Grants (German Research Foundation, Humboldt Foundation, Brandau-Laibach Foundation).
