A2 Refereed review article in a scientific journal
The interplay between organized lymphoid structures and thermogenic adipose tissue
Authors: Acosta, Francisco M.; Örling, Johanna; Salmi, Marko; Virtanen, Kirsi A.
Publisher: Elsevier BV
Publication year: 2025
Journal: Trends in Endocrinology and Metabolism
ISSN: 1043-2760
eISSN: 1879-3061
DOI: https://doi.org/10.1016/j.tem.2025.08.006
Publication's open availability at the time of reporting: Open Access
Publication channel's open availability : Partially Open Access publication channel
Web address : https://doi.org/10.1016/j.tem.2025.08.006
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/500394353
Advances in the immunometabolism field have shown that infiltrated immune cells play a pivotal role in the development and function of thermogenic adipose tissue (TAT), including brown and beige fat. However, scarce research has focused on the role that organized lymphoid structures, like lymph nodes and lymphatics vessels, may exert on TAT. In this review we summarize the evidence suggesting that a significant link exists between the lymphoid tissues and adipose tissue, and we describe the most important in vitro and in vivo findings indicating that organized lymphoid tissues also play an important role in TAT biogenesis and function, raising relevant questions which are still unsolved in this emerging field.
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Funding information in the publication:
This work was possible thanks to funding from the European Union’s Horizon 2027 research and innovation programme under the Marie Sklodowska-Curie grant (101065356), the Research Council of Finland (348017 to F.A.M., 343410 to K.A.V.), Research Council of Finland’s Flagship InFLAMES (337530 and 357910), Sigrid Juselius Foundation, Finnish Diabetes Research Foundation, K. Albin Johansson’s foundation, Varha state research funding, and the Tyks Foundation.
