A1 Refereed original research article in a scientific journal
Natural Inhibitors Against Severe Acute Respiratory Syndrome Coronavirus 2 Main Protease From Three Vietnamese Bryophytes
Authors: Le, Thi-Kim-Dung; Mach, Gia-Hai; Tram, Nguyen-Khanh-Trinh; Pham, Nguyen-Kim-Tuyen; Nguyen, Ngoc-Khanh-Van; Tran, Thi-Minh-Dinh; Vuong, Boi-Phong; Nguyen, Ngoc-Hong; Duong, Thuc-Huy; Choowongkomon, Kiattawee
Publisher: Wiley
Publication year: 2025
Journal: Chemistry and Biodiversity
Article number: e00907
ISSN: 1612-1872
eISSN: 1612-1880
DOI: https://doi.org/10.1002/cbdv.202500907
Publication's open availability at the time of reporting: No Open Access
Publication channel's open availability : Partially Open Access publication channel
Web address : https://doi.org/10.1002/cbdv.202500907
Erythrodontium julaceum, Marchantia polymorpha, and Plagiochila bantamensis are widely distributed bryophytes in Vietnam. However, comprehensive chemical and biological data on their composition remain limited. Bio-guided isolation based on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Mpro inhibition was applied to these species, resulting in the identification of 23 metabolites. Compound P8 is a new natural compound. Subsequently, the SARS-CoV-2 Mpro inhibition of the isolated compounds revealed that bisbibenzyl- and 3-benzylphthalide-type compounds exhibit bioactivity. Among the tested compounds, isoriccardin C (M2) and julacelide (E1) exhibited significant activity, with IC50 values of 15.7 and 2.84 mu g/mL, respectively. Molecular docking results further supported their strong activity.
Funding information in the publication:
This work is supported by Ho Chi Minh University of Education (CS2024.19.51)
