A1 Refereed original research article in a scientific journal
Natural Inhibitors Against Severe Acute Respiratory Syndrome Coronavirus 2 Main Protease From Three Vietnamese Bryophytes
Authors: Le, Thi-Kim-Dung; Mach, Gia-Hai; Tram, Nguyen-Khanh-Trinh; Pham, Nguyen-Kim-Tuyen; Nguyen, Ngoc-Khanh-Van; Tran, Thi-Minh-Dinh; Vuong, Boi-Phong; Nguyen, Ngoc-Hong; Duong, Thuc-Huy; Choowongkomon, Kiattawee
Publisher: Wiley
Publication year: 2025
Journal:: Chemistry and Biodiversity
Article number: e00907
ISSN: 1612-1872
eISSN: 1612-1880
DOI: https://doi.org/10.1002/cbdv.202500907
Web address : https://doi.org/10.1002/cbdv.202500907
Abstract
Erythrodontium julaceum, Marchantia polymorpha, and Plagiochila bantamensis are widely distributed bryophytes in Vietnam. However, comprehensive chemical and biological data on their composition remain limited. Bio-guided isolation based on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Mpro inhibition was applied to these species, resulting in the identification of 23 metabolites. Compound P8 is a new natural compound. Subsequently, the SARS-CoV-2 Mpro inhibition of the isolated compounds revealed that bisbibenzyl- and 3-benzylphthalide-type compounds exhibit bioactivity. Among the tested compounds, isoriccardin C (M2) and julacelide (E1) exhibited significant activity, with IC50 values of 15.7 and 2.84 mu g/mL, respectively. Molecular docking results further supported their strong activity.
Erythrodontium julaceum, Marchantia polymorpha, and Plagiochila bantamensis are widely distributed bryophytes in Vietnam. However, comprehensive chemical and biological data on their composition remain limited. Bio-guided isolation based on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Mpro inhibition was applied to these species, resulting in the identification of 23 metabolites. Compound P8 is a new natural compound. Subsequently, the SARS-CoV-2 Mpro inhibition of the isolated compounds revealed that bisbibenzyl- and 3-benzylphthalide-type compounds exhibit bioactivity. Among the tested compounds, isoriccardin C (M2) and julacelide (E1) exhibited significant activity, with IC50 values of 15.7 and 2.84 mu g/mL, respectively. Molecular docking results further supported their strong activity.
Funding information in the publication:
This work is supported by Ho Chi Minh University of Education (CS2024.19.51)
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