Systematic Review and Expert Consensus on the Use of Long-acting Monoclonal Antibodies for Prevention of Respiratory Syncytial Virus Disease: ARMADA (Advancing RSV Management And Disease Awareness) Taskforce
: Manzoni, Paolo; Baraldi, Eugenio; Midulla, Fabio; Claris, Olivier; Dessardo, Sandro; Heikkinen, Terho; Thwaites, Richard; Paes, Bosco; Carbonell-Estrany, Xavier; Dobryanskyy, Dmytro; Cetinkaya, Merih; Al Harbi, Adel S.; Kang, Ji-Man; Goh Eng Neo, Anne; Chi, Hsin; Sant'Anna, Guilherme; Villa Guillen, Monica; Mariani, Gonzalo Luis; Safadi, Marco Aurelio Palazzi; Urzua, Soledad; Zar, Heather J.; Goussard, Pierre; Rodgers-Gray, Barry; Waghorne, Nicola; Sanchez Luna, Manuel
Publisher: Oxford University Press (OUP)
: CARY
: 2025
: Open Forum Infectious Diseases
: Open Forum Infectious Diseases
: OPEN FORUM INFECT DI
: ofaf396
: 12
: 7
: 16
: 2328-8957
: 2328-8957
DOI: https://doi.org/10.1093/ofid/ofaf396
: https://doi.org/10.1093/ofid/ofaf396
: https://research.utu.fi/converis/portal/detail/Publication/499701893
Background: Long-acting monoclonal antibodies (LAmAbs) could dramatically reduce the respiratory syncytial virus (RSV) disease burden in children if implemented using clear, evidence-based recommendations.
Methods: The ARMADA Taskforce-an international, multidisciplinary expert panel-undertook a systematic review to develop LAmAbs consensus recommendations for RSV disease prevention in children.
Results: The Taskforce recommends LAmAbs for all infants aged <8 months in the absence of maternal RSV vaccination, preterm infants (<37 weeks' gestational age) aged <12 months, and children <24 months with high-risk conditions. Seasonal LAmAb administration is recommended, although in RSV-endemic countries decisions should be made locally concerning administration year-round or with peak RSV incidences.
Conclusions: The Taskforce strongly endorses LAmAbs implementation based on their efficacy, effectiveness, and public health impact. These recommendations provide a blueprint to inform guidelines worldwide. Wider equitable access to LAmAbs at affordable prices, especially in low- and middle-income countries is needed to reduce the childhood RSV burden.
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Financial support for this study was provided by Sanofi and AstraZeneca. The sponsors had no role in the selection of ARMADA participants, the preparation of the manuscript, or the decision to submit for publication.
