Long-term risk of dementia following hospitalization due to physical diseases: A multicohort study



: Pyry N Sipilä, Joni V Lindbohm, Archana Singh‐Manoux, Martin J. Shipley, Tuomo Kiiskinen, Aki S Havulinna, Jussi Vahtera, Solja T Nyberg, Jaana Pentti, Mika Kivimäki

Publisher: Elsevier Inc.

: 2020

: Alzheimer's and Dementia

: Alzheimer's & dementia : the journal of the Alzheimer's Association

: Alzheimers Dement

: 1552-5260

: 1552-5279

DOI: https://doi.org/10.1002/alz.12167

: https://research.utu.fi/converis/portal/detail/Publication/49912846


Conventional risk factors targeted by prevention (e.g., low education, smoking, and obesity) are associated with a 1.2- to 2-fold increased risk of dementia. It is unclear whether having a physical disease is an equally important risk factor for dementia.In this exploratory multicohort study of 283,414 community-dwelling participants, we examined 22 common hospital-treated physical diseases as risk factors for dementia.During a median follow-up of 19 years, a total of 3416 participants developed dementia. Those who had erysipelas (hazard ratio = 1.82; 95% confidence interval = 1.53 to 2.17), hypothyroidism (1.94; 1.59 to 2.38), myocardial infarction (1.41; 1.20 to 1.64), ischemic heart disease (1.32; 1.18 to 1.49), cerebral infarction (2.44; 2.14 to 2.77), duodenal ulcers (1.88; 1.42 to 2.49), gastritis and duodenitis (1.82; 1.46 to 2.27), or osteoporosis (2.38; 1.75 to 3.23) were at a significantly increased risk of dementia. These associations were not explained by conventional risk factors or reverse causation.In addition to conventional risk factors, several physical diseases may increase the long-term risk of dementia.

Last updated on 2024-26-11 at 20:51