A1 Refereed original research article in a scientific journal
Validation of a New Histopathologic Risk Model in Early Oral Tongue Cancer: A Combination of a Modified Worst Pattern of Invasion and a New Tumor Budding Score
Authors: Almangush, Alhadi; Salo, Tuula; Haglund, Caj; Kowalski, Luis Paulo; Hagström, Jaana; Coletta, Ricardo D; Mäkitie, Antti A; Leivo, Ilmo
Publication year: 2025
Journal: American Journal of Surgical Pathology
Journal name in source: The American journal of surgical pathology
Journal acronym: Am J Surg Pathol
ISSN: 0147-5185
eISSN: 1532-0979
DOI: https://doi.org/10.1097/PAS.0000000000002433
Web address : https://journals.lww.com/ajsp/fulltext/9900/validation_of_a_new_histopathologic_risk_model_in.540.aspx
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/498562127
Oral tongue squamous cell carcinoma (OTSCC) is the most common cancer of the oral cavity. A new histopathologic risk assessment has been recently introduced and we sought to validate its prognostic value in a large multicenter cohort of early-stage OTSCC. A total of 310 cases treated for early-stage OTSCC were included in this study. The assessment of modified worst pattern of invasion and a recently developed tumor budding score were performed in hematoxylin and eosin-stained sections. A statistically significant association was observed in the multivariable analysis between high score of the new risk model and worse disease-specific survival (HR: 2.54, 95% CI: 1.48-4.37, P<0.001). Similarly, in disease-free survival, the high-risk group was significantly associated with poor survival (HR: 1.66, 95% CI: 1.07-2.58, P=0.024). In conclusion, the new histopathologic risk model is a powerful prognostic indicator and can be assessed as part of routine diagnostic practice. Early-stage OTSCC patients with a high-risk score have a poor prognosis and therefore require a multimodality treatment strategy with a close clinical follow-up.
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