A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Unfolding the Mystery of Autoimmunity : The Environmental Determinants of Diabetes in the Young (TEDDY) Study
Tekijät: Rewers, Marian; Agardh, Daniel; Johnson, Suzanne Bennett; Bonifacio, Ezio; Larsson, Helena Elding; Gesualdo, Patricia; Hagopian, William; Haller, Michael J.; Hyöty, Heikki; Johnson, Randi; McIndoe, Richard; McKinney, Eoin; Melin, Jessica; Lernmark, Åke; Lloyd, Richard E.; Lynch, Kristian F.; Norris, Jill M.; Rich, Stephen S.; Roth, Roswith; Schatz, Desmond; Toppari, Jorma; Triplett, Eric; Vehik, Kendra; Virtanen, Suvi M.; Ziegler, Anette-G.; Akolkar, Beena; Krischer, Jeffrey P.; TEDDY Study Group
Kustantaja: American Diabetes Association
Julkaisuvuosi: 2025
Journal: Diabetes Care
Tietokannassa oleva lehden nimi: Diabetes care
Lehden akronyymi: Diabetes Care
Artikkelin numero: dc242886
ISSN: 0149-5992
eISSN: 1935-5548
DOI: https://doi.org/10.2337/dc24-2886
Verkko-osoite: https://doi.org/10.2337/dc24-2886
In 2025, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the National Institutes of Health celebrates 75 years of leadership in diabetes research. The NIDDK serves people of the U.S. affected by or at risk for many chronic diseases, including diabetes and other endocrine, metabolic, and digestive disorders, by funding innovative research to develop better treatment and prevention and a cure for these conditions. Autoimmunity that leads to type 1 diabetes or celiac disease or thyroid autoimmunity affects 1 in 20 children and adolescents in the U.S. While treatments are available, prevention of these common autoimmune diseases has been elusive due to poor understanding of the environmental causes and their interactions with common predisposing or protective genetic variants. In 2002, the NIDDK established The Environmental Determinants of Diabetes in the Young (TEDDY) consortium to advance understanding of the causes and the natural history of type 1 diabetes and other autoimmune diseases. The overarching goal of TEDDY is to inform novel approaches to primary prevention of autoimmunity. In this large international prospective birth cohort study, standardized information has been collected concerning candidate environmental exposures along with serial blood, stool, nasal swab, and other biosamples, with creation of a central repository of data and biologic samples for hypothesis-based research. This review summarizes TEDDY's major contributions to our understanding of environmental triggers, drivers, and modifiers of autoimmunity, and gene-environment interactions, leading to type 1 diabetes.
Julkaisussa olevat rahoitustiedot:
The TEDDY study is funded by the NIDDK, National Institute of Allergy and Infectious Diseases, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Environmental Health Sciences, CDC, and Breakthrough T1D (formerly JDRF) (grants U01 DK63829, U01 DK63861, U01 DK63821, U01 DK63865, U01 DK63863, U01 DK63836, U01 DK63790, UC4 DK63829, UC4 DK63861, UC4 DK63821, UC4 DK63865, UC4 DK63863, UC4 DK63836, UC4 DK95300, UC4 DK100238, UC4 DK106955, UC4 DK112243, UC4 DK117483, U01 DK124166, and U01 DK128847 and contract no. HHSN267200700014C). This work is supported in part by the NIH/National Center for Advancing Translational Sciences Clinical and Translational Science Awards to the University of Florida (UL1 TR000064) and the University of Colorado (UL1 TR002535).
The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.
