A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
A comprehensive p75 neurotrophin receptor gene network and pathway analyses identifying new target genes
Tekijät: Sajanti A, Lyne SB, Girard R, Frantzen J, Rantamaki T, Heino I, Cao Y, Diniz C, Umemori J, Li Y, Takala R, Posti JP, Roine S, Koskimaki F, Rahi M, Rinne J, Castren E, Koskimaki J
Kustantaja: NATURE RESEARCH
Julkaisuvuosi: 2020
Journal: Scientific Reports
Tietokannassa oleva lehden nimi: SCIENTIFIC REPORTS
Lehden akronyymi: SCI REP-UK
Artikkelin numero: ARTN 14984
Vuosikerta: 10
Numero: 1
Sivujen määrä: 9
ISSN: 2045-2322
DOI: https://doi.org/10.1038/s41598-020-72061-z
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/49808409
P75 neurotrophic receptor (p75NTR) is an important receptor for the role of neurotrophins in modulating brain plasticity and apoptosis. The current understanding of the role of p75NTR in cellular adaptation following pathological insults remains blurred, which makes p75NTR's related signaling networks an interesting and challenging initial point of investigation. We identified p75NTR and related genes through extensive data mining of a PubMed literature search including published works related to p75NTR from the past 20 years. Bioinformatic network and pathway analyses of identified genes (n=235) were performed using ReactomeFIViz in Cytoscape based on the highly reliable Reactome functional interaction network algorithm. This approach merges interactions extracted from human curated pathways with predicted interactions from machine learning. Genome-wide pathway analysis showed total of 16 enriched hierarchical clusters. A total of 278 enriched single pathways were also identified (p<0.05, false discovery rate corrected). Gene network analyses showed multiple known and new targets in the p75NTR gene network. This study provides a comprehensive analysis and investigation into the current knowledge of p75NTR signaling networks and pathways. These results also identify several genes and their respective protein products as involved in the p75NTR network, which have not previously been clearly studied in this pathway. These results can be used to generate novel hypotheses to gain a greater understanding of p75NTR in acute brain injuries, neurodegenerative diseases and general response to cellular damage.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
