B1 Vertaisarvioimaton kirjoitus tieteellisessä lehdessä
Lipid Profile Alterations during Fingolimod Treatment in Multiple Sclerosis Patients
Tekijät: Rauma I, Huhtala H, Soilu-Hänninen M, Kuusisto H
Kustantaja: SPRINGER
Julkaisuvuosi: 2020
Journal: Journal of Neuroimmune Pharmacology
Tietokannassa oleva lehden nimi: JOURNAL OF NEUROIMMUNE PHARMACOLOGY
Lehden akronyymi: J NEUROIMMUNE PHARM
Vuosikerta: 15
Aloitussivu: 567
Lopetussivu: 569
Sivujen määrä: 3
ISSN: 1557-1890
DOI: https://doi.org/10.1007/s11481-020-09937-4
Tiivistelmä
Fingolimod reduces inflammatory activity in multiple sclerosis (MS) by acting as a functional antagonist of sphingosine 1-phosphate (S1P) receptors. It has been suggested that S1P might also contribute to the antiatherogenic effect of high-density lipoprotein (HDL). We conducted a retrospective observational study using data of 72 MS patients from two Finnish hospital districts to find out whether lipid profiles change during treatment with fingolimod. A mixed-effects model with patient as a random effect was used to analyze lipid profile alterations. We found a statistically significant elevation in both total cholesterol (0.12 mmol/L per year) and HDL (0.04 mmol/L per year) during a median follow-up of 12 months, while low-density lipoprotein (LDL) and triglycerides remained unchanged. Since the mean elevation observed in both lipid values seems to be modest, we suggest that routine lipid profile monitoring is unnecessary during fingolimod treatment in MS patients without pre-existing cardiovascular comorbidities.
Fingolimod reduces inflammatory activity in multiple sclerosis (MS) by acting as a functional antagonist of sphingosine 1-phosphate (S1P) receptors. It has been suggested that S1P might also contribute to the antiatherogenic effect of high-density lipoprotein (HDL). We conducted a retrospective observational study using data of 72 MS patients from two Finnish hospital districts to find out whether lipid profiles change during treatment with fingolimod. A mixed-effects model with patient as a random effect was used to analyze lipid profile alterations. We found a statistically significant elevation in both total cholesterol (0.12 mmol/L per year) and HDL (0.04 mmol/L per year) during a median follow-up of 12 months, while low-density lipoprotein (LDL) and triglycerides remained unchanged. Since the mean elevation observed in both lipid values seems to be modest, we suggest that routine lipid profile monitoring is unnecessary during fingolimod treatment in MS patients without pre-existing cardiovascular comorbidities.
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