B1 Non-refereed article in a scientific journal

Lipid Profile Alterations during Fingolimod Treatment in Multiple Sclerosis Patients




AuthorsRauma I, Huhtala H, Soilu-Hänninen M, Kuusisto H

PublisherSPRINGER

Publication year2020

JournalJournal of Neuroimmune Pharmacology

Journal name in sourceJOURNAL OF NEUROIMMUNE PHARMACOLOGY

Journal acronymJ NEUROIMMUNE PHARM

Volume15

First page 567

Last page569

Number of pages3

ISSN1557-1890

DOIhttps://doi.org/10.1007/s11481-020-09937-4


Abstract
Fingolimod reduces inflammatory activity in multiple sclerosis (MS) by acting as a functional antagonist of sphingosine 1-phosphate (S1P) receptors. It has been suggested that S1P might also contribute to the antiatherogenic effect of high-density lipoprotein (HDL). We conducted a retrospective observational study using data of 72 MS patients from two Finnish hospital districts to find out whether lipid profiles change during treatment with fingolimod. A mixed-effects model with patient as a random effect was used to analyze lipid profile alterations. We found a statistically significant elevation in both total cholesterol (0.12 mmol/L per year) and HDL (0.04 mmol/L per year) during a median follow-up of 12 months, while low-density lipoprotein (LDL) and triglycerides remained unchanged. Since the mean elevation observed in both lipid values seems to be modest, we suggest that routine lipid profile monitoring is unnecessary during fingolimod treatment in MS patients without pre-existing cardiovascular comorbidities.



Last updated on 2024-26-11 at 22:18