A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Sleep disturbances, shift work, and epigenetic ageing in working-age adults: findings from the Young Finns study
Tekijät: Autio, Ida; Saarinen, Aino; Marttila, Saara; Raitoharju, Emma; Mishra, Pashupati P.; Mononen, Nina; Kähönen, Mika; Keltikangas-Järvinen, Liisa; Raitakari, Olli; Lehtimäki, Terho
Kustantaja: Springer Science and Business Media LLC
Kustannuspaikka: LONDON
Julkaisuvuosi: 2025
Journal: Clinical Epigenetics
Tietokannassa oleva lehden nimi: Clinical Epigenetics
Lehden akronyymi: CLIN EPIGENETICS
Artikkelin numero: 55
Vuosikerta: 17
Numero: 1
Sivujen määrä: 13
ISSN: 1868-7075
eISSN: 1868-7083
DOI: https://doi.org/10.1186/s13148-025-01860-w
Verkko-osoite: https://doi.org/10.1186/s13148-025-01860-w
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/491890130
Background: Sleep disturbances are known to have adverse effects on health, but knowledge on the effect of sleep disturbances on epigenetic ageing is limited. We investigated (1) whether symptoms of insomnia, obstructive sleep apnoea, sleep deprivation, and circadian rhythm lateness are associated with epigenetic ageing, and (2) whether years spent in shift work moderates these associations.
Methods: We used the population-based Young Finns data (n = 1618). Epigenetic clocks such as AgeDevHannum, AgeDevHorvath, AgeDevPheno, AgeDevGrim, and DunedinPACE were utilized to measure epigenetic ageing. Sleep was evaluated using various validated self-report questionnaires. Covariates included sex, array type, smoking status, health behaviours, socioeconomic factors, and cardiovascular health factors.
Results: Among the various sleep measures, obstructive sleep apnoea symptoms were most consistently linked to accelerated epigenetic ageing, as measured by AgeDevGrim and DunedinPACE. Insomnia, sleep deprivation, and years spent in shift work were not associated with epigenetic ageing after adjusting for health-related or socioeconomic covariates. Additionally, we found interactions between years spent in shift work and sleep disturbances when accounting for epigenetic ageing. Among those with little to no history of shift work, both insomnia and sleep deprivation were associated with more accelerated epigenetic ageing in AgeDevGrim when compared to long-term shift workers. However, the pace of epigenetic ageing (measured with DunedinPACE) appears to be higher in those with both sleep deprivation and longer history of shift work.
Conclusions: Among various sleep measures, symptoms of obstructive sleep apnoea appear to be most consistently associated with accelerated epigenetic ageing even after adjusting for various health-related and socioeconomic factors. Shift work seems to have a crucial role in the relationship between sleep disturbances and epigenetic ageing in working-age adults.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
Julkaisussa olevat rahoitustiedot:
Open Access funding provided by University of Helsinki (including Helsinki University Central Hospital). The Young Finns Study has been financially supported by the Academy of Finland: grants 356405, 322098, 286284, 134309 (Eye), 126925, 121584, 124282, 129378 (Salve), 117797 (Gendi), and 141071 (Skidi); the Social Insurance Institution of Finland; Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals (grant X51001); Juho Vainio Foundation; Paavo Nurmi Foundation; Finnish Foundation for Cardiovascular Research; Finnish Cultural Foundation; The Sigrid Juselius Foundation; Tampere Tuberculosis Foundation; Emil Aaltonen Foundation (grant 220255); Yrjö Jahnsson Foundation; Signe and Ane Gyllenberg Foundation; Diabetes Research Foundation of Finnish Diabetes Association; EU Horizon 2020 (grant 755320 for TAXINOMISIS and grant 848146 for To Aition); European Research Council (grant 742927 for MULTIEPIGEN project); Tampere University Hospital Supporting Foundation; Finnish Society of Clinical Chemistry; the Cancer Foundation Finland; pBETTER4U_EU (Preventing obesity through Biologically and bEhaviorally Tailored inTERventions for you; project number: 101080117); CVDLink (EU grant nro. 101137278) and the Jane and Aatos Erkko Foundation. Pashupati P. Mishra was supported by the Academy of Finland (grant 349708) and Emma Raitoharju by the Academy of Finland (grants 330809 and 338395).
