B1 Non-refereed article in a scientific journal

mTORC1 shutdown unleashes TFEB to drive triple-negative breast cancer invasion



Authors: Gounis, Michalis; Hamidi, Hellyeh; Ivaska, Johanna

Publisher: Elsevier BV

Publishing place: CAMBRIDGE

Publication year: 2025

Journal: Developmental Cell

Journal name in source: Developmental Cell

Journal acronym: DEV CELL

Volume: 60

Issue: 7

First page : 979

Last page: 981

Number of pages: 3

ISSN: 1534-5807

eISSN: 1878-1551

DOI: https://doi.org/10.1016/j.devcel.2025.03.006

Web address : https://doi.org/10.1016/j.devcel.2025.03.006


Abstract
The PI3K/AKT/mTOR pathway is considered a key therapeutic target in triple-negative breast cancer (TNBC). In this issue of Developmental Cell, Remy et al. challenge this idea by demonstrating that mTORC1 inhibition activates TFEB, promoting MT1-MMP exocytosis, ECM degradation, and increased cell invasion, especially when combined with chemotherapy.



Last updated on 2025-07-05 at 14:16