A1 Refereed original research article in a scientific journal
Incidence of new onset arterial hypertension after metabolic bariatric surgery: an 8-year prospective follow-up with matched controls
Authors: Vahtera, Viiko; Pajarinen, Jukka S.; Kivimäki, Mika; Ervasti, Jenni; Pentti, Jaana; Stenholm, Sari; Vahtera, Jussi; Salminen, Paulina
Publisher: Lippincott, Williams & Wilkins
Publishing place: PHILADELPHIA
Publication year: 2025
Journal: Journal of Hypertension
Journal name in source: Journal of Hypertension
Journal acronym: J HYPERTENS
Volume: 43
Issue: 5
First page : 871
Last page: 879
Number of pages: 9
ISSN: 0263-6352
eISSN: 1473-5598
DOI: https://doi.org/10.1097/HJH.0000000000003993
Web address : https://doi.org/10.1097/hjh.0000000000003993
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/491618160
Background: Metabolic bariatric surgery (MBS) reduces the risk of new-onset hypertension; however, it is unclear whether this effect varies according to patient sex, age, or socioeconomic background. This study aimed to assess the risk of new-onset arterial hypertension after MBS, with a special focus on these patient characteristics.
Methods: This follow-up study with matched controls was nested in a large employee cohort, the Finnish Public Sector study, consisting of individuals with no hypertension at baseline. For each patient who underwent laparoscopic MBS between 2008 and 2016, two propensity-score matched controls were selected from individuals hospitalized with a diagnosis of obesity or individuals with self-reported severe obesity [body mass index (BMI) ≥ 35 kg/m 2 ] but no recorded history of MBS. Cases of new-onset hypertension were identified via linked electronic health records from the national health registries until December 31, 2016.
Results: The study included 912 patients and 1780 matched controls. The rate of new-onset hypertension per 1000 person-years was 2.8 in the surgery group and 9.6 in the control group, with a rate ratio of 0.29 (95% confidence intervals 0.15-0.57) and a rate difference of -6.8 (95% confidence intervals -9.6 to -4.0) per 1000 person-years. No significant differences in rate reduction after MBS were observed to be associated with patient sex, age, or socioeconomic status.
Conclusion: Metabolic bariatric surgery reduces the risk of new-onset arterial hypertension across all age-, sex-, and socioeconomic subgroups.
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Funding information in the publication:
Viiko Vahtera was supported by ERVA research funding from the Hospital District of Southwest Finland (VTR 13136), Finnish Society of Gastrointestinal Surgeons, Finnish Association of Bariatric and Metabolic Surgery (LIME), Doctoral Program in Clinical Research of the University of Turku, Turku, Finland. Mika Kivimäki was supported by the Wellcome Trust (221854/Z/20/Z), UK Medical Research Council (MRC S011676/1, R024227/1), US National Institute on Aging (R01AG056477), Academy of Finland (350426), and Finnish Foundation for Cardiovascular Research (a86898). Jenni Ervasti was supported by the Academy of Finland, Strategic Research Council (358458), and Finnish Work Environment Fund (220245). Sari Stenholm was supported by the Academy of Finland (332030). Jussi Vahtera was supported by Academy of Finland (329240). Paulina Salminen was supported by the Sigrid Jusélius lius Foundation.
Disclosure: Dr Paulina Salminen reports on lecture fees from Novo Nordisk. All other authors declare no competing interests.
