The seventh annual Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS) 2022 took place in sunny West Palm Beach, Florida. Over the three days of February 24-26, the ACTRIMS forum brought together 1500+ in-person and virtual participants. The conference highlighted novel scientific discoveries for multiple sclerosis (MS), focusing on MS biomarkers. I attended numerous informative sessions where I learned more about the role of various biomarkers in MS diagnosis and management as well as innovative developments in the field.