A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Social disadvantage accelerates aging
Tekijät: Kivimaki, Mika; Pentti, Jaana; Frank, Philipp; Liu, Fangyu; Blake, Acer; Nyberg, Solja T.; Vahtera, Jussi; Singh-Manoux, Archana; Wyss-Coray, Tony; Walker, Keenan A.; Partridge, Linda; Lindbohm, Joni V.
Kustantaja: Springer Science and Business Media LLC
Kustannuspaikka: BERLIN
Julkaisuvuosi: 2025
Journal: Nature Medicine
Tietokannassa oleva lehden nimi: Nature Medicine
Lehden akronyymi: NAT MED
Vuosikerta: 31
Aloitussivu: 1635
Lopetussivu: 1643
Sivujen määrä: 26
ISSN: 1078-8956
eISSN: 1546-170X
DOI: https://doi.org/10.1038/s41591-025-03563-4
Verkko-osoite: https://doi.org/10.1038/s41591-025-03563-4
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/491573959
Social disadvantage, like advanced age, is a risk factor for a broad range of health conditions; however, whether it influences the aging process remains unclear. Here, using a multicohort approach, we investigated the associations of social disadvantage with age-related plasma proteins and age-related diseases. We found proteomic signatures of accelerated immune aging and 14 specific age-related proteins linked to social disadvantage during both early and later life. Individuals experiencing social disadvantage had an increased risk of 66 age-related diseases, with up to 39% of these associations mediated by the 14 age-related proteins (for example, DNAJB9, F2, HSPA1A, BGN). The main enriched pathway involved the upregulation of the pro-inflammatory regulator NF-kappa B24 and its downstream factor interleukin-8. Our findings support the hypothesis that social disadvantage throughout the life course may accelerate aging, a biological mechanism that could explain why social stratification plays such a fundamental role in determining human health.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
Julkaisussa olevat rahoitustiedot:
Wellcome Trust Collaborative Award in Science and the Intramural Research Program of the National Institute on Aging (NIA)
