A1 Refereed original research article in a scientific journal

Risk of Vulvar HSIL and Penile Neoplasias in Anogenital Lichen Planus: A Case-Control Study




AuthorsHieta, Niina K.; Tapana, Lotta; Söderlund, Jenni M.; Huvila, Jutta K.; Talve, Lauri A.I.; Haataja, Marjut A.M.

PublisherLippincott, Williams & Wilkins

Publication year2025

JournalJournal of Lower Genital Tract Disease

Journal name in sourceJournal of Lower Genital Tract Disease

ISSN1089-2591

eISSN1526-0976

DOIhttps://doi.org/10.1097/LGT.0000000000000879(external)

Web address https://doi.org/10.1097/lgt.0000000000000879(external)

Self-archived copy’s web addresshttps://research.utu.fi/converis/portal/detail/Publication/491451670(external)


Abstract

Objective: Lichen planus (LP) is a chronic inflammatory skin disease that may affect the skin, scalp, nails, and mucosa. The aim of this study was to investigate the risk of genital premalignant and malignant conditions in patients with anogenital LP (agLP).

Methods: We identified 60 male and 56 female patients with agLP by searching the biobank archives for a genital or perianal skin biopsy showing LP between 2004 and 2020. We also included 10 randomly selected age- and sex-matched controls for each patient. The risks of genital cancers and their precursors were evaluated.

Results: The incidence of agLP was 1.54 per 100,000 men and 1.36 per 100,000 women. There was no statistical difference between male and female incidence (p = .5721). The odds ratio (OR) for high-grade squamous intraepithelial lesion (HSIL) of the vulva was 31.2 (95% CI = 2.46-1645.00; p = .01). The OR for penile neoplasias could not be calculated because control patients had no neoplasias, but the difference was suggestive of statistical significance (95% CI = 1.90-infinite; p = .008). The mean age at the time of diagnosis of agLP was 59.9 years (median 62 years) in female patients and 40.8 years (median 33 years) in male patients. The difference in the mean ages of female and male patients was statistically significant (95% CI = 11.92-26.13; p < .001).

Conclusions: Patients with agLP may have an increased risk for vulvar HSIL and penile neoplasia.


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Funding information in the publication
This work was supported by a grant from the Turku University Hospital (Project 13287).


Last updated on 2025-27-05 at 13:50