In the digital transformation era, inclusive innovations have become increasingly crucial with their exclusive role in bridging the socioeconomic gaps in emerging economies. This research study examines the role of Information and Communication Technology (ICT) in empowering grassroots entrepreneurs as one way to contribute to fostering inclusive innovations. Through qualitative methods, the study conducts a deep analysis of case studies and interviews first with entrepreneurs and supporting actors from the institutional level of the Tanzanian innovation ecosystem in order to understand the growth journeys of startups and the role of actors in promoting innovation. The study continues with interviews with grassroots entrepreneurs who utilize ICT to overcome barriers in access to information and market reach. Firstly, the findings of this study revealed an integrated innovation model which includes a series of processes done by higher education institutions in promoting creativity, innovation and entrepreneurship including successes and challenges. Secondly, through activities and processes organized by innovation hubs to promote inclusive innovation the study revealed that a clear understanding of inclusive innovation is needed. Thirdly, the study identified some factors that positively influence the growth of technology startups and support organizations that are the most active in contributing to their growth and success. Lastly, the study also demonstrated how ICT plays a critical role as an enabler, providing access to resources, enhancing skill development and expanding market opportunities for entrepreneurs. The implications established by the study show the need for more community level innovation hubs to address local challenges, a need to contextualize institutional level approaches, the necessary for an expansion of inclusivity through community centered- campaigns, and a promotion of participatory policy design.