A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Maternal Smoking Intensity During Pregnancy and Early Adolescent Cardiovascular Health
Tekijät: Liu, Mengjiao; Soon, Elna Yihui; Lange, Katherine; Juonala, Markus; Kerr, Jessica A.; Liu, Richard; Dwyer, Terence; Wake, Melissa; Burgner, David; Li, Ling-Jun
Kustantaja: WILEY
Kustannuspaikka: HOBOKEN
Julkaisuvuosi: 2025
Journal: Journal of the American Heart Association
Tietokannassa oleva lehden nimi: JOURNAL OF THE AMERICAN HEART ASSOCIATION
Lehden akronyymi: J AM HEART ASSOC
Artikkelin numero: e037806
Vuosikerta: 14
Numero: 5
Sivujen määrä: 11
eISSN: 2047-9980
DOI: https://doi.org/10.1161/JAHA.124.037806
Verkko-osoite: https://www.ahajournals.org/doi/10.1161/JAHA.124.037806
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/491383645
Background: The adverse cardiovascular effects of smoking are well established. We aimed to investigate the less well-understood effects of pregnancy smoke exposure on offspring cardiovascular health in early adolescence.
Methods and Results: Data were drawn from the nationally representative Longitudinal Study of Australian Children's Child Health CheckPoint. Mothers reported mean daily cigarettes smoked in each trimester (<= 10 versus >10/day), and smoking cessation during pregnancy. Blood pressure, pulse wave velocity, carotid intima-media thickness, and retinal microvascular parameters were measured in early adolescence (mean 11.5 years). Hypertension was defined as systolic blood pressure >= 120 or diastolic blood pressure >= 80 mm Hg. 187 (11.8%) of 1582 women (mean age 30.7 +/- 0.2 years), smoked during pregnancy, of whom 143 (76.5%) smoked throughout pregnancy, and 58 (31.0%) smoked >10 cigarettes/day. Compared with those born to nonsmoking mothers, the odds of hypertension in early adolescence were 1.44 (95% CI, 1.01-2.06) if mothers ever smoked, 1.99 (1.22-3.24) if mothers smoked >10 cigarettes/day, and 1.64 (1.11-2.42) if mothers smoked throughout pregnancy There was limited evidence of associations between smoking throughout pregnancy and other cardiovascular measures. Offspring of mothers who stopped smoking during pregnancy and nonsmokers had similar cardiovascular measures, apart from hypertension.
Conclusions: Offspring of mothers who smoked in pregnancy have increased risks of hypertension in adolescence, with increased risk with greater exposure intensity and duration. Mothers who stopped smoking during pregnancy had offspring with similar cardiovascular health to those born to nonsmokers. Our findings underscore the importance of specific strategies to stop maternal smoking before conception and during pregnancy.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
Julkaisussa olevat rahoitustiedot:
The Child Health CheckPoint was supported by the National Health and Medical Research Council of Australia (1041352, 1109355), The Royal Children's Hospital Foundation (2014‐241), the Murdoch Children's Research Institute, the University of Melbourne, the National Heart Foundation of Australia (100660), and the Financial Markets Foundation for Children (2014‐055, 2016‐310). Research at Murdoch Children's Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program. Mengjiao Liu is supported by the Chunhui Program, Department of International Cooperation and Exchange, Ministry of Education (HZKY20220393) and the Science and Technology Department of Jiangxi Province Natural Science Foundation of Jiangxi Province (20232BAB216103). Melissa Wake is supported by a National Health and Medical Research Council Principal Research Fellowship (GTN1160906) and was supported by Cure Kids New Zealand. David Burgner was supported by a National Health and Medical Research Council Investigator Grant (GTN1175744). Ling‐Jun Li is supported by the National Medical Research Council Clinician Scientist Award (MOH‐000711‐01).
