A2 Refereed review article in a scientific journal
Recent Advances and Impact of Chemotherapeutic and Antiangiogenic Nanoformulations for Combination Cancer Therapy
Authors: Amit Kumar Rajora, Divyashree Ravishankar, Hongbo Zhang, Jessica M. Rosenholm
Publisher: MDPI
Publication year: 2020
Journal: Pharmaceutics
Journal name in source: PHARMACEUTICS
Journal acronym: PHARMACEUTICS
Article number: 592
Volume: 12
Issue: 6
Number of pages: 26
eISSN: 1999-4923
DOI: https://doi.org/10.3390/pharmaceutics12060592
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/49097167
Traditional chemotherapy, along with antiangiogenesis drugs (combination cancer therapy), has shown reduced tumor recurrence and improved antitumor effects, as tumor growth and metastasis are often dependent on tumor vascularization. However, the effect of combination chemotherapy, including synergism and additive and even antagonism effects, depends on drug combinations in an optimized ratio. Hence, nanoformulations are ideal, demonstrating a great potential for the combination therapy of chemo-antiangiogenesis for cancer. The rationale for designing various nanocarriers for combination therapy is derived from organic (polymer, lipid), inorganic, or hybrid materials. In particular, hybrid nanocarriers that consist of more than one material construct provide flexibility for different modes of entrapment within the same carrier-e.g., physical adsorption, encapsulation, and chemical conjugation strategies. These multifunctional nanocarriers can thus be used to co-deliver chemo- and antiangiogenesis drugs with tunable drug release at target sites. Hence, this review attempts to survey the most recent advances in nanoformulations and their impact on cancer treatment in a combined regimen-i.e., conventional cytotoxic and antiangiogenesis agents. The mechanisms and site-specific co-delivery strategies are also discussed herein, along with future prospects.
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