A1 Refereed original research article in a scientific journal
Influence of 2 '-fucosyllactose and galacto-oligosaccharides on the growth and adhesion of Streptococcus mutans
Authors: Salli K, Soderling E, Hirvonen J, Gursoy UK, Ouwehand AC
Publisher: Cambridge University Press
Publication year: 2020
Journal: British Journal of Nutrition
Journal name in source: BRITISH JOURNAL OF NUTRITION
Journal acronym: BRIT J NUTR
Volume: 124
Issue: 8
First page : 824
Last page: 831
Number of pages: 8
ISSN: 0007-1145
eISSN: 1475-2662
DOI: https://doi.org/10.1017/S0007114520001956
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/49072885
Human milk oligosaccharides, such as 2 '-fucosyllactose (2 '-FL), and galacto-oligosaccharides (GOS), a prebiotic carbohydrate mixture, are being increasingly added to infant formulas, necessitating the understanding of their impact on the oral microbiota. Here, for the first time, the effects of 2 '-FL and GOS on the planktonic growth and adhesion characteristics of the caries-associated oral pathogenStreptococcus mutanswere assessed, and the results were compared against the effects of xylitol, lactose and glucose. There were differences inS. mutansgrowth between 2 '-FL and GOS. None of the threeS. mutansstrains grew with 2 '-FL, while they all grew with GOS as well as lactose and glucose. Xylitol inhibitedS. mutansgrowth. The adhesion ofS. mutansCI 2366 to saliva-coated hydroxyapatite was reduced by 2 '-FL and GOS. Exopolysaccharide-mediated adhesion ofS. mutansDSM 20523 to a glass surface was decreased with 2 '-FL, GOS and lactose, and the adhesion of strain CI 2366 strain was reduced only by GOS. Unlike GOS, 2 '-FL did not support the growth of anyS. mutansstrain. Neither 2 '-FL nor GOS enhanced the adhesive properties of theS. mutansstrains, but they inhibited some of the tested strains. Thus, the cariogenic tendency may vary between infant formulas containing different types of oligosaccharides.
Downloadable publication This is an electronic reprint of the original article. |  |
