A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma
Tekijät: Johansson P, Krona C, Kundu S, Doroszko M, Baskaran S, Schmidt L, Vinel C, Almstedt E, Elgendy R, Elfineh L, Gallant C, Lundsten S, Gago FJF, Hakkarainen A, Sipila P, Haggblad M, Martens U, Lundgren B, Frigault MM, Lane DP, Swartling FJ, Uhrbom L, Nestor M, Marino S, Nelander S
Kustantaja: CELL PRESS
Julkaisuvuosi: 2020
Journal: Cell Reports
Tietokannassa oleva lehden nimi: CELL REPORTS
Lehden akronyymi: CELL REP
Artikkelin numero: ARTN 107897
Vuosikerta: 32
Numero: 2
Sivujen määrä: 25
ISSN: 2211-1247
DOI: https://doi.org/10.1016/j.celrep.2020.107897
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/48996948
Glioblastoma (GBM) is a malignant brain tumor with few therapeutic options. The disease presents with a complex spectrum of genomic aberrations, but the pharmacological consequences of these aberrations are partly unknown. Here, we report an integrated pharmacogenomic analysis of 100 patient-derived GBM cell cultures from the human glioma cell culture (HGCC) cohort. Exploring 1,544 drugs, we find that GBM has two main pharmacological subgroups, marked by differential response to proteasome inhibitors and mutually exclusive aberrations in TP53 and CDKN2A/B. We confirm this trend in cell and in xenotransplantation models, and identify both Bcl-2 family inhibitors and p53 activators as potentiators of proteasome inhibitors in GBM cells, We can further predict the responses of individual cell cultures to several existing drug classes, presenting opportunities for drug repurposing and design of stratified trials. Our functionally profiled biobank provides a valuable resource for the discovery of new treatments for GBM.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
