B1 Non-refereed article in a scientific journal

Good guy in bad company: How STRNs convert PP2A into an oncoprotein



Authors: Kurppa Kari J, Westermarck Jukka

Publication year: 2020

Journal: Cancer Cell

Volume: 38

Issue: 1

First page : 20

Last page: 22

Number of pages: 4

ISSN: 1535-6108

eISSN: 1878-3686

DOI: https://doi.org/10.1016/j.ccell.2020.06.011

Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/48901298


Abstract

Certain Protein Phosphatase 2A (PP2A) complexes are human tumor suppressors. In contrast, a paper in this issue of Cancer Cell and two other recent studies demonstrate that PP2A-STRN3/4 complexes inactivate Hippo tumor suppressor pathway, resulting in YAP activation and tumorigenesis. Furthermore, this new oncogenic phosphatase mechanism may be druggable


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Last updated on 2024-26-11 at 23:23