A2 Refereed review article in a scientific journal
Risk stratification in oral squamous cell carcinoma using staging of the eighth American Joint Committee on Cancer: Systematic review and meta-analysis
Authors: Alhadi Almangush, Matti Pirinen, Omar Youssef, Antti A. Mäkitie, Ilmo Leivo
Publisher: WILEY
Publication year: 2020
Journal: Head and Neck
Journal name in source: HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
Journal acronym: HEAD NECK-J SCI SPEC
Volume: 42
Issue: 10
Number of pages: 16
ISSN: 1043-3074
eISSN: 1097-0347
DOI: https://doi.org/10.1002/hed.26344
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/48716422
The eighth edition of the American Joint Committee on Cancer (AJCC8) staging manual has major changes in oral squamous cell carcinoma (OSCC). We searched PubMed, OvidMedline, Scopus, and Web of Science for studies that examined the performance of AJCC8 in OSCC. A total of 40 808 patients were included in the studies of our meta-analysis. A hazard ratio (HR) of 1.87 (95%CI 1.78-1.96) was seen for stage II, 2.65 (95%CI 2.51-2.80) for stage III, 3.46 (95%CI 3.31-3.61) for stage IVa, and 7.09 (95%CI 4.85-10.36) for stage IVb. A similar gradual increase in risk was noted for the N classification. For the T classification, however, there was a less clear variation in risk between T3 and T4. AJCC8 provides a good risk stratification for OSCC. Future research should examine the proposals introduced in the published studies to further improve the performance of AJCC8.
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