A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä

Long non-coding RNAs in cutaneous biology and keratinocyte carcinomas




TekijätPiipponen Minna, Nissinen Liisa, Kähäri Veli-Matti

KustantajaSpringer

Julkaisuvuosi2020

JournalCellular and Molecular Life Sciences

Tietokannassa oleva lehden nimiCellular and Molecular Life Sciences

Vuosikerta77

Aloitussivu4601

Lopetussivu4614

Sivujen määrä14

ISSN1420-682X

eISSN1420-9071

DOIhttps://doi.org/10.1007/s00018-020-03554-3

Rinnakkaistallenteen osoitehttps://research.utu.fi/converis/portal/detail/Publication/48540074


Tiivistelmä

Long non-coding RNAs (lncRNAs) are a largely uncharacterized group of
non-coding RNAs with diverse regulatory roles in various biological
processes. Recent observations have elucidated the functional roles of
lncRNAs in cutaneous biology, e.g. in proliferation and
differentiation of epidermal keratinocytes and in cutaneous wound
repair. Furthermore, the role of lncRNAs in keratinocyte-derived skin
cancers is emerging, especially in cutaneous squamous cell carcinoma
(cSCC), which presents a significant burden to health care services
worldwide and causes high mortality as metastatic disease. Elucidation
of the functions of keratinocyte-specific lncRNAs will improve
understanding of the molecular pathogenesis of epidermal disorders and
skin cancers and can be exploited in development of new diagnostic and
therapeutic applications for keratinocyte carcinomas. In this review, we
summarize the current evidence of functionally important lncRNAs in
cutaneous biology and in keratinocyte carcinomas.


Ladattava julkaisu

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Last updated on 2024-26-11 at 21:38