A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Molecular Mechanisms of Heat Shock Factors in Cancer
Tekijät: Mikael Christer Puustinen, Lea Sistonen
Kustantaja: MDPI
Julkaisuvuosi: 2020
Journal: Cells
Tietokannassa oleva lehden nimi: CELLS
Lehden akronyymi: CELLS-BASEL
Artikkelin numero: 1202
Vuosikerta: 9
Numero: 5
Sivujen määrä: 20
eISSN: 2073-4409
DOI: https://doi.org/10.3390/cells9051202
Verkko-osoite: https://www.mdpi.com/2073-4409/9/5/1202
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/48517562
Tiivistelmä
Malignant transformation is accompanied by alterations in the key cellular pathways that regulate development, metabolism, proliferation and motility as well as stress resilience. The members of the transcription factor family, called heat shock factors (HSFs), have been shown to play important roles in all of these biological processes, and in the past decade it has become evident that their activities are rewired during tumorigenesis. This review focuses on the expression patterns and functions of HSF1, HSF2, and HSF4 in specific cancer types, highlighting the mechanisms by which the regulatory functions of these transcription factors are modulated. Recently developed therapeutic approaches that target HSFs are also discussed.
Malignant transformation is accompanied by alterations in the key cellular pathways that regulate development, metabolism, proliferation and motility as well as stress resilience. The members of the transcription factor family, called heat shock factors (HSFs), have been shown to play important roles in all of these biological processes, and in the past decade it has become evident that their activities are rewired during tumorigenesis. This review focuses on the expression patterns and functions of HSF1, HSF2, and HSF4 in specific cancer types, highlighting the mechanisms by which the regulatory functions of these transcription factors are modulated. Recently developed therapeutic approaches that target HSFs are also discussed.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
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