A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Covalently Mercurated 6‐Phenylcarbazole Residues Promote Hybridization of Triplex‐Forming Oligonucleotides
Tekijät: Ukale, Dattatraya Uttam; Lönnberg, Tuomas
Kustannuspaikka: WEINHEIM
Julkaisuvuosi: 2025
Lehti: ChemBioChem
Tietokannassa oleva lehden nimi: ChemBioChem
Lehden akronyymi: CHEMBIOCHEM
Artikkelin numero: e202401006
Sivujen määrä: 8
ISSN: 1439-4227
eISSN: 1439-7633
DOI: https://doi.org/10.1002/cbic.202401006
Julkaisun avoimuus kirjaamishetkellä: Ei avoimesti saatavilla
Julkaisukanavan avoimuus : Osittain avoin julkaisukanava
Verkko-osoite: https://doi.org/10.1002/cbic.202401006
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/485153979
Rinnakkaistallennetun julkaisun versio: Final draft
Homothymidine DNA oligonucleotides bearing a 3'-terminal 6-phenyl-9H-carbazole C-nucleoside, mercurated at position 1, 8 or both, were synthesized and tested for their potential to form triple helices with homoadenine & sdot; homothymine duplexes. The monomercurated triplex-forming oligonucleotides favored hybridization with fully matched double helices and in some cases considerable increase of the melting temperature could be attributed to Hoogsteen-type Hg(II)-mediated interaction with the homoadenine strand. The dimercurated one, on the other hand, favored hybridization with double helices placing a homo mispair opposite to the carbazole residue, suggesting that simultaneous coordination of each of the two Hg(II) ions to a different strand is only possible in the absence of competition from Watson-Crick base pairing.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
Julkaisussa olevat rahoitustiedot:
Finnish Cultural Foundation
