This study explores the main obstacles and potential solutions for implementing mental health initiatives to promote innovation in Nigerian small businesses within Industry 5.0. Using a qualitative approach and the Socio-Technical Systems (STS) framework. Key barriers identified include organizational resistance, financial constraints, awareness gaps, and sociocultural issues. Specific challenges to digital mental health solutions involve erratic human behavior, mental illness stigma, and inadequate IT infrastructure. The study underscores the importance of social and behavioral factors in the acceptance and security of digital interventions and the complexity of integrating social and technical systems. It advocates for collaboration between social and technical experts, human-centric design, advanced technologies, supportive corporate culture, and ongoing learning. Comprehensive digital interventions and incorporating mental health into talent management are essential for a healthy and innovative work environment.