A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Aggressive Subtypes of Laryngeal Chondrosarcoma and their Clinical Behavior: A Systematic Review
Tekijät: Piazza, Cesare; Montenegro, Claudia; Tomasoni, Michele; Leivo, Ilmo; Stenman, Göran; Agaimy, Abbas; Simpson, Roderick H. W.; Zidar, Nina; Ferlito, Alfio
Kustantaja: Springer Science and Business Media LLC
Julkaisuvuosi: 2025
Journal: Oncology and therapy
Tietokannassa oleva lehden nimi: Oncology and Therapy
Vuosikerta: 13
Aloitussivu: 49
Lopetussivu: 67
ISSN: 2366-1070
eISSN: 2366-1089
DOI: https://doi.org/10.1007/s40487-024-00323-1
Verkko-osoite: https://doi.org/10.1007/s40487-024-00323-1
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/485010727
Introduction
Laryngeal chondrosarcoma (CS) is a rare indolent malignant tumor. High-grade (G3), dedifferentiated (DD), and myxoid (MY) CSs are considered more aggressive subtypes due to their metastatic potential and relatively poor outcomes. The aim of this systematic review is to evaluate treatment modalities and survival outcomes in patients affected by these rarer CS subtypes.
MethodsPapers published from January 1, 2000, to August 25, 2024, describing cases of laryngeal G3, DD, and MY CS were included.
ResultsA total of 38 patients (15 G3, 13 DD, and 10 MY) were selected. Cricoid cartilage was the most common site of origin. Total laryngectomy (TL) was often performed. Primary conservative approaches in 42.8% of patients were followed by loco-regional recurrence.
ConclusionsAggressive subtypes of CS require a radical approach because of the higher rate of loco-regional and distant recurrences compared to low-grade CS. TL with radical intent is the most common treatment, and adjuvant therapy should be considered after careful multidisciplinary discussion.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
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No funding or sponsorship was received for this study or publication of this article.
