A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Birth weight and head circumference for 22–29 weeks gestation neonates from an international cohort
Tekijät: Fenton, Tanis R; Alshaikh, Belal; Kusuda, Satoshi; Helenius, Kjell; Modi, Neena; Norman, Mikael; Lui, Kei; Lehtonen, Liisa; Battin, Malcolm; Klinger, Gil; Vento, Maximo; Lastrucci, Vieri; Gagliardi, Luigi; Adams, Mark; Marba, Sérgio T M; Isayama, Tetsuya; Hakansson, Stellan; Bassler, Dirk; Shah, Prakesh S; International Network for Evaluation of Outcomes (iNeo) of Neonates Investigators
Kustantaja: BMJ
Kustannuspaikka: LONDON
Julkaisuvuosi: 2025
Journal: Archives of Disease in Childhood Fetal and Neonatal Edition
Tietokannassa oleva lehden nimi: Archives of Disease in Childhood - Fetal and Neonatal Edition
Lehden akronyymi: ARCH DIS CHILD-FETAL
Sivujen määrä: 8
ISSN: 1359-2998
eISSN: 1468-2052
DOI: https://doi.org/10.1136/archdischild-2024-327845
Verkko-osoite: https://doi.org/10.1136/archdischild-2024-327845
Objective: Size at birth is a key indicator of in utero growth. Our objective was to generate sex-specific percentiles for birth weight and head circumference in neonates born between 22 and 29 weeks gestation from pregnancies without hypertension or diabetes and assess differences between vaginal and caesarean births and between singletons and twins.
Methods: We used data from 12 countries participating in the International Network for Evaluating Outcomes in Neonates database from 2007 to 2021. We excluded data that were influenced by truncation with 1500g birth weight cut-offs in databases and neonates with major congenital anomalies or born to mothers with hypertension or diabetes.
Results: After exclusions, 132 727 neonates contributed to birth weight and 65 406 contributed to head circumference. The percentiles of birth weight were similar between countries at the 50th and 90th percentiles, though variability was noted in the lower percentiles from countries with smaller sample sizes. Head circumference percentiles were comparable between countries. Caesarean births had birth weights similar to vaginal births until 26 weeks after which the weight at 10th percentile diverged by approximately 239 g at 29 weeks. Vaginal births had birth weights very similar to Hadlock's intrauterine estimated fetal weights. There were no differences in head circumference between vaginal and caesarean births and between singletons and twins.
Conclusions: We present updated information on weight and head circumference at birth for preterm neonates of 22-29 weeks gestation born to mothers without hypertension or diabetes derived from a large multicountry cohort. Research is needed to explore the predictive value of these birth size data for health and developmental outcomes.
Julkaisussa olevat rahoitustiedot:
The International Network for Evaluating Outcomes (iNeo) of neonates has been supported by the Canadian Institutes of Health Research (APR-126340 and PBN 150642 to PSS). The Australian and New Zealand Neonatal Network is predominantly funded by membership contributions from the participating centres. The Canadian Neonatal Network is supported by Canadian Preterm Birth Network Grant (Canadian Institutes of Health Research Grant for the Canadian Preterm Birth Network (PBN 150642)), the Mount Sinai Hospital and the participating centres. The Finnish Medical Birth Register is governmentally funded and kept by the National Institute for Health and Welfare (THL). The Israel Neonatal Network very low birth weight infant database is partially funded by the Israel Center for Disease Control and the Ministry of Health. The Neonatal Research Network of Japan is partly funded by a Health Labour Sciences Research Grant from the Ministry of Health, Labour and Welfare of Japan. The Spanish Neonatal Network is supported by funds from the Spanish Neonatal Society (SENeo). The Swedish Neonatal Quality Register is funded by the Swedish Government (Ministry of Health and Social Affairs), the Swedish Association of Local Communities and Regions (SALAR) and the participating units. The Swiss Neonatal Network is partially funded by the participating units in the form of membership fees. This research was also supported by Instituto de Investigación Sanitaria Carlos III (Ministry of Science, Innovation and Universities, Kingdom of Spain) (FIS17/0131 to MV); and RETICS funded by the PN 2018-2021 (Spain), ISCIII–Sub-Directorate General for Research Assessment and Promotion, and the European Regional Development Fund (ERDF) (RD16/0022); and by grants from a regional agreement on clinical research (ALF) between Region Stockholm and Karolinska Institutet (2020-0443 to MN). The UK National Neonatal Research Database and the UK Neonatal Collaborative receive no core funding and are supported through cost recovery from supported research.
