A1 Refereed original research article in a scientific journal
Age-Related Variations in Takotsubo Syndrome
Authors: Cammann V.L., Szawan K.A., Stähli B.E., Kato K., Budnik M., Wischnewsky M., Dreiding S., Levinson R.A., Di Vece D., Gili S., Citro R., Bossone E., Neuhaus M., Franke J., Meder B., Jaguszewski M., Noutsias M., Knorr M., Heiner S., D'Ascenzo F., Dichtl W., Burgdorf C., Kherad B., Tschöpe C., Sarcon A., Shinbane J., Rajan L., Michels G., Pfister R., Cuneo A., Jacobshagen C., Karakas M., Koenig W., Pott A., Meyer P., Roffi M., Banning A., Wolfrum M., Cuculi F., Kobza R., Fischer T.A., Vasankari T., Airaksinen K.E.J., Napp L.C., Dworakowski R., MacCarthy P., Kaiser C., Osswald S., Galiuto L., Chan C., Bridgman P., Beug D., Delmas C., Lairez O., Gilyarova E., Shilova A., Gilyarov M., El-Battrawy I., Akin I., Poledniková K., Toušek P., Winchester D.E., Galuszka J., Ukena C., Poglajen G., Carrilho-Ferreira P., Hauck C., Paolini C., Bilato C., Kobayashi Y., Shoji T., Ishibashi I., Takahara M., Himi T., Din J., Al-Shammari A., Prasad A., Rihal C.S., Liu K., Schulze P.C., Bianco M., Jörg L., Rickli H., Pestana G., Nguyen T.H., Böhm M., Maier L.S., Pinto F.J., Widimský P., Felix S.B., Braun-Dullaeus R.C., Rottbauer W., Hasenfuß G., Pieske B.M., Schunkert H., Borggrefe M., Thiele H., Bauersachs J., Katus H.A., Horowitz J.D., Di Mario C., Münzel T., Crea F., Bax J.J., Lüscher T.F., Ruschitzka F., Ghadri J.R., Opolski G., Templin C.
Publisher: ELSEVIER SCIENCE INC
Publication year: 2020
Journal: Journal of the American College of Cardiology
Journal name in source: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
Journal acronym: J AM COLL CARDIOL
Volume: 75
Issue: 16
First page : 1869
Last page: 1877
Number of pages: 9
ISSN: 0735-1097
DOI: https://doi.org/10.1016/j.jacc.2020.02.057
Web address : https://www.sciencedirect.com/science/article/pii/S0735109720344661?via%3Dihub
Background: Takotsubo syndrome (TTS) occurs predominantly in post-menopausal women but is also found in younger patients.
Objectives: This study aimed to investigate age-related differences in TTS.
Methods: Patients diagnosed with TTS and enrolled in the International Takotsubo Registry between January 2011 and February 2017 were included in this analysis and were stratified by age (younger: ≤50 years, middle-age: 51 to 74 years, elderly: ≥75 years). Baseline characteristics, hospital course, as well as short- and long-term mortality were compared among groups.
Results: Of 2,098 TTS patients, 242 (11.5%) patients were ≤50 years of age, 1,194 (56.9%) were 51 to 74 years of age, and 662 (31.6%) were ≥75 years of age. Younger patients were more often men (12.4% vs. 10.9% vs. 6.3%; p = 0.002) and had an increased prevalence of acute neurological (16.3% vs. 8.4% vs. 8.8%; p = 0.001) or psychiatric disorders (14.1% vs. 10.3% vs. 5.6%; p < 0.001) compared with middle-aged and elderly TTS patients. Furthermore, younger patients had more often cardiogenic shock (15.3% vs. 9.1% vs. 8.1%; p = 0.004) and had a numerically higher in-hospital mortality (6.6% vs. 3.6% vs. 5.1%; p = 0.07). At multivariable analysis, younger (odds ratio: 1.60; 95% confidence interval: 0.86 to 3.01; p = 0.14) and older age (odds ratio: 1.09; 95% confidence interval: 0.66 to 1.80; p = 0.75) were not independently associated with in-hospital mortality using the middle-aged group as a reference. There were no differences in 60-day mortality rates among groups.
Conclusions: A substantial proportion of TTS patients are younger than 50 years of age. TTS is associated with severe complications requiring intensive care, particularly in younger patients.
