A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Tertiary lymphoid structures in nasopharyngeal carcinoma: A multi-institutional study
Tekijät: Almangush, Alhadi; Ruuskanen, Miia; Hagström, Jaana; Kosma, Veli-Matti; Mäkitie, Antti A.; Leivo, Ilmo
Kustantaja: Elsevier BV
Kustannuspaikka: MUNICH
Julkaisuvuosi: 2025
Journal: Pathology - Research and Practice
Tietokannassa oleva lehden nimi: Pathology - Research and Practice
Lehden akronyymi: PATHOL RES PRACT
Artikkelin numero: 155789
Vuosikerta: 266
Sivujen määrä: 5
ISSN: 0344-0338
eISSN: 1618-0631
DOI: https://doi.org/10.1016/j.prp.2024.155789
Verkko-osoite: https://doi.org/10.1016/j.prp.2024.155789
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/484580464
Background: Tertiary lymphoid structures (TLSs) associate with prognosis of many malignancies. However, the clinical significance of TLSs is not well-elucidated in nasopharyngeal carcinoma (NPC) patients.
Material and methods: In this whole population-based multicenter study, a total of 115 patients treated for NPC were included. The patients were treated at the five Finnish university hospitals. TLSs were assessed in routine hematoxylin and eosin (HE)-stained sections.
Results: Presence of TLSs associates significantly with improved survival in NPC. Absence of TLSs had a significant association with a poor disease-specific survival of NPC with a hazard ratio (HR) of 1.96 (95 % CI 1.09-3.53, P = 0.025) in the multivariable analysis. Similarly, absence of TLSs associated with worse overall survival with a HR of 1.68 (95 % CI 1.02-2.75, P = 0.040).
Conclusion: TLSs seem to be associated with prognosis of NPC patients. Having TLSs in NPC tumors correlates with good survival. The assessment of TLSs could aid in understanding the clinical behavior and in planning the treatment of NPC.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
Julkaisussa olevat rahoitustiedot:
Finnish Cancer Society, Turku University Hospital Fund, Finska Läkaresällskapet, Maritza and Reino Salonen Foundation, K. Albin Johansson Foundation, Finnish Dental Society Apollonia, Helsinki University Hospital Research Fund, and Sigrid Jusélius Foundation.
