Quantitative synthesis of dynamic combinatorial macrocycles accelerated by preorganization of AIEgens for live visualization of drug release - UTU Research Portal

A1 Refereed original research article in a scientific journal

Quantitative synthesis of dynamic combinatorial macrocycles accelerated by preorganization of AIEgens for live visualization of drug release

Authors: Yang, Jinghui; Wang, Xin; Wu, Xiaoxia; Lyu, Yonglei; Papageorgiou, Anastassios C.; Li, Jianwei

Publisher: CELL PRESS

Publishing place: CAMBRIDGE

Publication year: 2025

Journal: Cell Reports Physical Science

Journal name in source: CELL REPORTS PHYSICAL SCIENCE

Journal acronym: CELL REP PHYS SCI

Article number: 102355

Volume: 6

Issue: 1

Number of pages: 10

eISSN: 2666-3864

DOI: https://doi.org/10.1016/j.xcrp.2024.102355

Web address : https://doi.org/10.1016/j.xcrp.2024.102355

Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/484285226

Abstract

In the aggregated state, restricted molecular movement leads to decreased entropy, a phenomenon closely associated with the release of luminescence known as aggregation-induced emission (AIE). This unique optical property is used in optoelectronic devices, biochemical sensors, and bioimaging. Complementing AIE's optical characteristics, we report that AIE-related preorganization can catalyze chemical reactions, yielding highly selective products. These products can affect aggregation states, modulating fluorescence. Incorporating an anticancer drug into this system intensified entropy reduction, accelerated reactions, and altered nanostructure. The drug's electron-donating properties quench fluorescence via energy transfer with the AIE molecule. These components engage in reversible reactions and noncovalent interactions, creating responsive nanosystems for real-time drug release visualization in drug-resistant cancer cells. This synergy between AIE and in situ dynamic covalent reactions offers a promising strategy for synthesizing specific molecules and exploring adaptive nanosystems with advanced optical properties for biomedical applications.

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Funding information in the publication:
We are grateful for the financial support from the Sigrid Juselius Foundation (Senior Researcher Fellowship to J.L.) and the Academy of Finland (decision no. 318524, project funding to J.L.). J.Y. and X. Wu acknowledge the support from the China Scholarship Council. A.C.P. thanks Biocenter Finland for infrastructure support. We thank the Turku Center for Chemical and Molecular Analytics for providing NMR and the Electron Microscopy Laboratory, Institute of Biomedicine, University of Turku, and Biocenter Finland for TEM imaging. We thank Prof. M. Vilanova (Universitat de Girona, Spain) for her generous donation of the NCI/ADR-RES cells.