B2 Vertaisarvioimaton kirjan tai muun kokoomateoksen osa
Bioaffinity Recognition of Extracellular Vesicle Glycosylations
Tekijät: Islam, Khirul; Leivo, Janne
Toimittaja: Rilla, Kirsi
Painos: 1
Kustantaja: Springer Science and Business Media Deutschland GmbH
Julkaisuvuosi: 2024
Kokoomateoksen nimi: Extracellular Vesicles as Matrix Messengers
Tietokannassa oleva lehden nimi: Biology of Extracellular Matrix
Sarjan nimi: Biology of Extracellular Matrix
Numero sarjassa: 15
Vuosikerta: 15
Aloitussivu: 243
Lopetussivu: 265
ISBN: 978-3-031-68810-2
eISBN: 978-3-031-68811-9
ISSN: 0887-3224
eISSN: 2191-1959
DOI: https://doi.org/10.1007/978-3-031-68811-9_10
Verkko-osoite: https://link.springer.com/chapter/10.1007/978-3-031-68811-9_10
Extracellular vesicles (EVs) are rapidly gaining attention for their functional role in intercellular communication and their potential value as noninvasive biomarkers of various pathologies. EV glycosylations have been identified as potent functional molecules that govern the vesicles’ biological roles and dictate their pathophysiological relevance. In this chapter, we review the glycosylation landscape of EVs and their biological function, along with the analytical tools used to study them. In addition, the most widely used carbohydrate-specific natural and synthetic affinity scaffolds currently used to study the glycosylations on EVs are described. The development of specific bioaffinity tools, such as glycan-specific antibodies, remains challenging due to the inherent low immunogenicity of glycans. Alternative strategies, including the use of recombinant immunoglobulins, aptamers, and molecular imprinted polymer derivatives, are actively explored to overcome these hurdles and harness the full potential of EV glycosylations in both basic glycobiology research and clinical applications.
Julkaisussa olevat rahoitustiedot:
The authors would like to acknowledge Research Council of Finland’s Flagship InFLAMES (decision numbers: 337530 and 357910).
