Device-Measured 24-Hour Movement Behaviors and Blood Pressure: A 6-Part Compositional Individual Participant Data Analysis in the ProPASS Consortium




Blodgett, Joanna M.; Ahmadi, Matthew N.; Atkin, Andrew J.; Pulsford, Richard M.; Rangul, Vegar; Chastin, Sebastien; Chan, Hsiu-Wen; Suorsa, Kristin; Bakker, Esmée A.; Gupta, Nidhi; Hettiarachchi, Pasan; Johansson, Peter J.; Sherar, Lauren B.; del Pozo Cruz, Borja; Koemel, Nicholas; Mishra, Gita D.; Eijsvogels, Thijs M.H.; Stenholm, Sari; Hughes, Alun D.; Teixeira-Pinto, Armando; Ekelund, Ulf; Lee, I-Min; Holtermann, Andreas; Koster, Annemarie; Stamatakis, Emmanuel; Hamer, Mark; ProPASS Collaboration

PublisherLippincott Williams and Wilkins

2025

Circulation

Circulation

151

2

159

170

0009-7322

1524-4539

DOIhttps://doi.org/10.1161/CIRCULATIONAHA.124.069820

https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.124.069820

https://research.utu.fi/converis/portal/detail/Publication/478111908



BACKGROUND: Blood pressure (BP)-lowering effects of structured exercise are well-established. Effects of 24-hour movement behaviors captured in free-living settings have received less attention. This cross-sectional study investigated associations between a 24-hour behavior composition comprising 6 parts (sleeping, sedentary behavior, standing, slow walking, fast walking, and combined exercise-like activity [eg, running and cycling]) and systolic BP (SBP) and diastolic BP (DBP).

METHODS: Data from thigh-worn accelerometers and BP measurements were collected from 6 cohorts in the Prospective Physical Activity, Sitting and Sleep consortium (ProPASS) (n=14 761; mean±SD, 54.2±9.6 years). Individual participant analysis using compositional data analysis was conducted with adjustments for relevant harmonized covariates. Based on the average sample composition, reallocation plots examined estimated BP reductions through behavioral replacement; the theoretical benefits of optimal (ie, clinically meaningful improvement in SBP [2 mm Hg] or DBP [1 mm Hg]) and minimal (ie, 5-minute reallocation) behavioral replacements were identified.

RESULTS: The average 24-hour composition consisted of sleeping (7.13±1.19 hours), sedentary behavior (10.7±1.9 hours), standing (3.2±1.1 hours), slow walking (1.6±0.6 hours), fast walking (1.1±0.5 hours), and exercise-like activity (16.0±16.3 minutes). More time spent exercising or sleeping, relative to other behaviors, was associated with lower BP. An additional 5 minutes of exercise-like activity was associated with estimated reductions of -0.68 mm Hg (95% CI, -0.15, -1.21) SBP and -0.54 mm Hg (95% CI, -0.19, 0.89) DBP. Clinically meaningful improvements in SBP and DBP were estimated after 20 to 27 minutes and 10 to 15 minutes of reallocation of time in other behaviors into additional exercise. Although more time spent being sedentary was adversely associated with SBP and DBP, there was minimal impact of standing or walking.

CONCLUSIONS: Study findings reiterate the importance of exercise for BP control, suggesting that small additional amounts of exercise are associated with lower BP in a free-living setting.


This project was funded by a British Heart Foundation special grant (SP/F/20/150002) and National Health and Medical Research Council (Australia) investigator (APP1194510) and ideas (APP1180812) grants. The establishment of the ProPASS consortium was supported by an unrestricted 2018-20 grant by PAL Technologies (Glasgow, United Kingdom). ActiPASS development was partly funded by FORTE, Swedish Research Council for Health, Working Life and Welfare (2021-01561). M.N.A. is supported by the National Heart Foundation (APP 107158). E.S. is funded by a National Health and Medical Research Council Investigator Grant (APP1194510). G.D.M. is supported by a National Health and Medical Research Council principal research fellowship (APP1121844). A.D.H. receives support from the British Heart Foundation, the Horizon 2020 Framework and the Horizon Europe Programme of the European Union, the National Institute for Health Research University College London Hospitals Biomedical Research Centre, the United Kingdom Medical Research Council, the National Institute for Health Research, and the Wellcome Trust, and works in a unit that receives support from the United Kingdom Medical Research Council. E.A.B. has received funding from the European Union Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement (No. 101064851).


Last updated on 2025-03-02 at 17:24