A1 Refereed original research article in a scientific journal
Dual physiological responsive structural color hydrogel particles for wound repair
Authors: Wang, Li; Fan, Lu; Filppula, Anne M.; Wang, Yu; Bian, Feika; Shang, Luoran; Zhang, Hongbo
Publisher: KeAi Communications
Publishing place: BEIJING
Publication year: 2025
Journal: Bioactive Materials
Journal name in source: BIOACTIVE MATERIALS
Journal acronym: BIOACT MATER
Volume: 46
First page : 494
Last page: 502
Number of pages: 9
eISSN: 2452-199X
DOI: https://doi.org/10.1016/j.bioactmat.2025.01.002
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/478067319
Hydrogel-based patches have demonstrated their values in diabetic wounds repair, particularly those intelligent dressings with continuous repair promoting and monitoring capabilities. Here, we propose a type of dual physiological responsive structural color particles for wound repair. The particles are composed of a hyaluronic acid methacryloyl (HAMA)-sodium alginate (Alg) inverse opal scaffold, filled with oxidized dextran (ODex)/ quaternized chitosan (QCS) hydrogel. The photo-polymerized HAMA and ionically cross-linked Ca-Alg constitute to the dual-network hydrogel with stable structural color. Furthermore, the ODex/QCS hydrogel, combined with glucose oxidase (GOX), exhibits pH/glucose dual responsiveness. Moreover, antimmicrobial peptide (AMP) plus vascular endothelial growth factor (VEGF) are comprised within the GOX-doped ODex/QCS hydrogel. In the high-glucose wound environment, GOX catalyzes glucose to generate acidic products, triggering rapid release of AMP and VEGF. Importantly, this process also leads to structural color changes of the particles, offering significant potential for wound monitoring. It has been demonstrated that such particles greatly promote the healing progress of diabetic wound in vivo. These results indicate that the present dual responsive particles would find valuable applications in diabetic wounds repair and the associated areas.
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Funding information in the publication:
Li Wang and Lu Fan contribute equally to this paper. This work was supported by the National Key Research and Development Program of China (2022YFA1105300), the National Natural Science Foundation of China (82372145, 82102181, 52403189), the Natural Science Foundation of Jiangsu Province (BK20210009) the Nanjing Distinguished Young Scholars Foundation (JQX22002). This work is supported by the Research Project (347897), Solution for Health Profile (336355), InFLAMES Flagship (337531), and "Printed Intelligence Infrastructure" (PII-FIRI)” from Research Council of Finland. This study is part of the activities of the Åbo Akademi University Foundation (SÅA) funded Center of Excellence in Research "Materials-driven solutions for combating antimicrobial resistance (MADNESS)" at ÅAU.
