A2 Refereed review article in a scientific journal

Cardiovascular positron emission tomography imaging of fibroblast activation: A review of the current literature



Authors: Loganath, Krithika; Craig, Neil; Barton, Anna; Joshi, Shruti; Anagnostopoulos, Constantinos; Erba, Paola Anna; Glaudemans, Andor W.J.M.; Saraste, Antti; Bucerius, Jan; Lubberink, Mark; Gheysens, Olivier; Buechel, Ronny R.; Habib, Gilbert; Gaemperli, Oliver; Gimelli, Alessia; Hyafil, Fabien; Newby, David E.; Slart, Riemer H.J.A.; Dweck, Marc R.

Publisher: Elsevier BV

Publication year: 2024

Journal: Journal of Nuclear Cardiology

Journal name in source: Journal of Nuclear Cardiology

Journal acronym: J Nucl Cardiol

Article number: 102106

ISSN: 1071-3581

eISSN: 1532-6551

DOI: https://doi.org/10.1016/j.nuclcard.2024.102106

Web address : https://doi.org/10.1016/j.nuclcard.2024.102106

Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/478058647


Abstract
Fibrosis is one of the key healing responses to injury, especially within the heart where it helps to maintain structural integrity following acute insults such as myocardial infarction. However, if it becomes dysregulated then fibrosis can become maladaptive leading to adverse remodelling, impaired cardiac function and heart failure. Fibroblast activation protein is exclusively expressed by activated fibroblasts, the key effector cells of fibrogenesis, and has a unique extracellular domain that is an ideal ligand for novel molecular imaging probes. Fibroblast activation protein inhibitor (FAPI) radiotracers have been developed for PET imaging, demonstrating high selectivity for activated fibroblasts across a range of different pathologies and disparate organ systems. In this review, we will summarize the role of fibroblast activation protein in cardiovascular disease and how FAPI radiotracers might improve the assessment and treatment of patients with cardiovascular diseases.

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Funding information in the publication: 
No funding was received for this review.


Last updated on 2025-21-02 at 13:28