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Human ROBO1 regulates white matter structure in corpus callosum
Tekijät: Darki, Fahimeh; Massinen, Satu; Salmela, Elina; Matsson, Hans; Peyrard-Janvid, Myriam; Klingberg, Torkel; Kere, Juha
Kustantaja: SPRINGER HEIDELBERG
Kustannuspaikka: HEIDELBERG
Julkaisuvuosi: 2017
Lehti:Brain Structure and Function
Tietokannassa oleva lehden nimiBRAIN STRUCTURE & FUNCTION
Lehden akronyymi: BRAIN STRUCT FUNCT
Vuosikerta: 222
Numero: 2
Aloitussivu: 707
Lopetussivu: 716
Sivujen määrä: 10
ISSN: 1863-2653
eISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-016-1240-y
Verkko-osoite: https://link.springer.com/article/10.1007/s00429-016-1240-y
Tiivistelmä
The axon guidance receptor, Robo1, controls the pathfinding of callosal axons in mice. To determine whether the orthologous ROBO1 gene is involved in callosal development also in humans, we studied polymorphisms in the ROBO1 gene and variation in the white matter structure in the corpus callosum using both structural magnetic resonance imaging and diffusion tensor magnetic resonance imaging. We found that five polymorphisms in the regulatory region of ROBO1 were associated with white matter density in the posterior part of the corpus callosum pathways. One of the polymorphisms, rs7631357, was also significantly associated with the probability of connections to the parietal cortical regions. Our results demonstrate that human ROBO1 may be involved in the regulation of the structure and connectivity of posterior part of corpus callosum.
The axon guidance receptor, Robo1, controls the pathfinding of callosal axons in mice. To determine whether the orthologous ROBO1 gene is involved in callosal development also in humans, we studied polymorphisms in the ROBO1 gene and variation in the white matter structure in the corpus callosum using both structural magnetic resonance imaging and diffusion tensor magnetic resonance imaging. We found that five polymorphisms in the regulatory region of ROBO1 were associated with white matter density in the posterior part of the corpus callosum pathways. One of the polymorphisms, rs7631357, was also significantly associated with the probability of connections to the parietal cortical regions. Our results demonstrate that human ROBO1 may be involved in the regulation of the structure and connectivity of posterior part of corpus callosum.
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