A1 Refereed original research article in a scientific journal

High-sensitivity cardiac troponin T and N-terminal b-type natriuretic propeptide are associated with cardiac and all-cause mortality in older adults – A population-based ten-year follow-up study




AuthorsHeikkilä, Elisa; Katajamäki, Taina; Salminen, Marika; Irjala, Kerttu; Viljanen, Anna, Koivula, Marja-Kaisa: Pulkki, Kari; Viitanen, Matti; Vahlberg, Tero; Viikari, Laura

PublisherElsevier B.V.

Publication year2025

JournalClinica Chimica Acta

Journal name in sourceClinica Chimica Acta

Article number120116

Volume567

ISSN0009-8981

eISSN1873-3492

DOIhttps://doi.org/10.1016/j.cca.2024.120116

Web address https://doi.org/10.1016/j.cca.2024.120116

Self-archived copy’s web addresshttps://research.utu.fi/converis/portal/detail/Publication/477798177


Abstract

Background: Cardiac troponin T (cTnT) and N-terminal B-type natriuretic propeptide (proBNP) are mainly used as biomarkers to diagnose specific conditions of the heart, but they also have predictive ability. Our aim was to study their associations with cardiovascular and all-cause mortality in an older population in non-acute conditions.

Methods: A population-based study with a ten-year follow-up. The data comes from a community-based representative sample of an older population with 1260 participants (participation rate 82 %). Associations were analyzed using Cox proportional hazard models.

Results: Altogether, 467 (37%) subjects died during the 10-year follow-up period, and 149 of those of a cardiovascular disease. Both elevated cTnT and proBNP concentrations were statistically significantly associated with cardiovascular and all-cause mortality in older adults.

Conclusions: Our study shows that older population with higher cTnT and proBNP concentrations have an increased risk of cardiovascular and all-cause mortality. Acknowledging the elevated risk may aid in targeting follow-up, prevention, and treatment adequately and more individually.


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Funding information in the publication
This study was financially supported by the Research Foundation for Laboratory Medicine, ERVA funding of the Turku University Hospital, the Finnish Society of Clinical Chemistry, and the Betania Foundation. The financial sponsors played no role in the design, execution, analysis, and interpretation of data.


Last updated on 2025-02-04 at 15:42