A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Better cardiometabolic/inflammatory profile is associated with differences in the supraclavicular adipose tissue activity of individuals with T2DM
Tekijät: Bonfante, Ivan Luiz Padilha; Segantim, Higor da Silva; Mendonça, Kauê Neto Soares; de Oliveira, Murilo Augusto Belmiro; Monfort-Pires, Milena; Duft, Renata Garbellini; Mateus, Keryma Chaves da Silva; Chacon-Mikahil, Mara Patricia Traina; Ramos, Celso Darío; Velloso, Licio Augusto; Cavaglieri, Cláudia Regina
Kustantaja: Springer Nature
Kustannuspaikka: NEW YORK
Julkaisuvuosi: 2024
Journal: Endocrine
Tietokannassa oleva lehden nimi: Endocrine
Lehden akronyymi: ENDOCRINE
Sivujen määrä: 11
ISSN: 1355-008X
eISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-024-04122-6
Verkko-osoite: https://doi.org/10.1007/s12020-024-04122-6
Purpose
Brown adipose tissue (BAT), located in the supraclavicular region, has been associated with a better cardiometabolic profile and reduced risk of developing non-communicable chronic diseases (NCD), in addition to being associated with a healthier phenotype in obesity. However, it is unknown whether greater supraclavicular adipose tissue activity could be associated with a healthier metabolic profile in people already diagnosed with type 2 diabetes (T2DM). Thus, the present work evaluated if supraclavicular adipose tissue activity is associated with metabolic and molecular markers in individuals with T2DM.
Methods
Based on a cluster study, individuals with T2DM were divided into groups according to high or low-standard uptake value (SUV) evaluated in the supraclavicular adipose tissue area by [18F]-fluorodeoxyglucose and positron emission tomography-computed tomography (18F-FDG-PET/CT) after mild cold exposure). Functional, biochemical, inflammatory, and molecular markers were measured.
Results
When we evaluated the whole sample, women showed higher SUV, which favored a difference between groups in sex-related markers. On the other hand, volunteers in the high-SUV group showed lower BMI, monocytes count, triglycerides/glucose index (TYG-index) and z score of metabolic syndrome (MS) values, as well as lower triglycerides, and VLDL concentrations. Moreover, they also had enhanced expression of thermogenic genes in subcutaneous fat. When analyzing only women, the differences in markers associated with sex disappear, and a lower count of leukocytes, platelets, along with lower TYG-index, z score of MS values, and triglycerides, VLDL, LDL, and TNF alpha concentrations were observed in women with the high SUV. In addition, higher expression of thermogenic genes and BECN1 were detected.
Conclusion
Higher supraclavicular adipose tissue SUV in individuals with T2DM is associated with a better cardiometabolic/inflammatory profile and expression of thermogenic genes.
Clinical trial registration
UTN: U1111-1202-1476 - 08/20/2020.
Julkaisussa olevat rahoitustiedot:
The study was supported by São Paulo State Research Support Foundation (FAPESP) – São Paulo/Brazil – Regular Research Grants – Process: 2016/08751-3; Coordination for the Improvement of Higher Education Personnel (CAPES) - Brazil – Financing Code 001; National Council for Scientific and Technological Development (CNPQ) – Brazil - Financing Code 303571/2018-7.
