A1 Refereed original research article in a scientific journal
Relationship of non-melancholic and melancholic depressive symptoms with all-cause mortality: A prospective study in a primary care population
Authors: Ansa Talvikki Rantanen, Mika Martin Kallio, Jyrki Jaakko Antero Korkeila, Hannu Kautiainen, Päivi Elina Korhonen
Publisher: Elsevier
Publication year: 2020
Journal: Journal of Psychosomatic Research
Journal name in source: Journal of psychosomatic research
Journal acronym: J Psychosom Res
Article number: 110107
Volume: 133
Number of pages: 7
ISSN: 0022-3999
eISSN: 1879-1360
DOI: https://doi.org/10.1016/j.jpsychores.2020.110107
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/47468445
To assess relationship of non-melancholic and melancholic subtypes of depressive symptoms with all-cause mortality among cardiovascular risk persons.A population-based prospective study of 2522 Finnish middle-aged persons with elevated cardiovascular risk was conducted. Depressive symptoms were assessed by the Beck's Depression Inventory. Data on mortality were obtained from The Official Statistics of Finland after 11-year follow-up.At baseline, the prevalence of non-melancholic and melancholic depressive symptoms was 14.9% and 5.2%, respectively. During the mean follow-up time of 11 years, 8.1% (n = 164) of those without, 13.9% (n = 52) of those with non-melancholic, and 10.7% (n = 14) of those with melancholic depressive symptoms died. Compared to non-depressive subjects, the hazard ratio for time to all-cause mortality was 1.67 (95% CI: 1.21-2.32, p = .002) in non-melancholically depressive and 1.01 (95% CI: 0.56-1.83, p = .97) in melancholically depressive subjects, when adjusted for age, gender, education, smoking, alcohol use, BMI, hypertension, dyslipidaemia, and glucose disorders. In comparison to the mortality rate in the general population throughout Finland over the same period, non-depressiveness was associated with a decreased standardized mortality rate.Non-melancholic depressive symptoms seem to be associated with excess all-cause mortality. In clinical settings, recognition of non-melancholic depressive symptoms should be emphasised.
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