A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Therapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular 18F-FDG Uptake in Atherosclerotic Mice
Tekijät: Mia Ståhle, Johanna M.U. Silvola, Sanna Hellberg, Margreet de Vries, Paul H. A. Quax, Jeffrey Kroon, Petteri Rinne, Alwin de Jong, Heidi Liljenbäck, Nina Savisto, Anna Wickman, Erik S.G. Stroes, Seppo Ylä-Herttuala, Pekka Saukko, Tommy Abrahamsson, Knut Pettersson, Juhani Knuuti, Anne Roivainen, Antti Saraste,
Kustantaja: Elsevier Inc
Julkaisuvuosi: 2020
Journal: JACC: Basic to Translational Science
Tietokannassa oleva lehden nimi: JACC: Basic to Translational Science
Vuosikerta: 5
Numero: 4
Aloitussivu: 360
Lopetussivu: 373
ISSN: 2452-302X
eISSN: 2452-302X
DOI: https://doi.org/10.1016/j.jacbts.2020.01.008
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/47290852
This study showed that treatment with a therapeutic monoclonal immunoglobulin-G1 antibody against phosphorylcholine on oxidized phospholipids preserves coronary flow reserve and attenuates atherosclerotic inflammation as determined by the uptake of 18F-fluorodeoxyglucose in atherosclerotic mice. The noninvasive imaging techniques represent translational tools to assess the efficacy of phosphorylcholine-targeted therapy on coronary artery function and atherosclerosis in clinical studies.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
