A1 Refereed original research article in a scientific journal
Respiratory infections regulated blood cells IFN-beta-PD-L1 pathway in pediatric asthma
Authors: Kölle J, Haag P, Vuorinen T, Alexander K, Rauh M, Zimmermann T, Papadopoulos NG, Finotto S
Publisher: WILEY
Publication year: 2020
Journal: Immunity, Inflammation and Disease
Journal name in source: IMMUNITY INFLAMMATION AND DISEASE
Journal acronym: IMMUN INFLAMM DIS
Volume: 8
Issue: 3
Number of pages: 10
eISSN: 2050-4527
DOI: https://doi.org/10.1002/iid3.307
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/47224553
Background Respiratory infections, in general, and rhinovirus infection specifically are the main reason for asthma exacerbation in children and programmed cell death protein 1 ligand (PD-L1) expression inhibits T cell responses.Objective Could the interferon (IFN) type I expression in peripheral blood mononuclear cells (PBMCs) improve disease exacerbation in pediatric asthma?Results Here we found increased level of PD-L1 messenger RNA (mRNA) in total blood cells isolated from preschool children with virus-induced asthma, with lower percentage of forced expiratory volume in 1 second and with high serum levels of the C-reactive-protein.Conclusions and Clinical Relevance These data indicate that, in the presence of infection in the airways of preschool children, worse asthma is associated with induced PD-L1 mRNA expression in blood cells. Further, type I IFN, IFN-beta, a cytokine that is involved in the clearance of infections, was found to be associated with a better lung function in asthmatic children. These data suggest that improving peripheral blood IFN type I expression in PBMCs in pediatric asthma could improve disease exacerbation due to suppressing PD-L1 expression in blood cells.
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