A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Tracking of Vascular Measures From Infancy to Early Childhood: A Cohort Study
Tekijät: Mansell, Toby; Nuotio, Joel; Vuillermin, Peter; Ponsonby, Anne-Louise; Lawlor, Deborah A.; McCloskey, Kate; Juonala, Markus; Burgner, David P.
Kustantaja: Ovid Technologies (Wolters Kluwer Health)
Kustannuspaikka: HOBOKEN
Julkaisuvuosi: 2024
Journal: Journal of the American Heart Association
Tietokannassa oleva lehden nimi: Journal of the American Heart Association
Lehden akronyymi: J AM HEART ASSOC
Artikkelin numero: e036611
Vuosikerta: 13
Numero: 21
Sivujen määrä: 8
eISSN: 2047-9980
DOI: https://doi.org/10.1161/JAHA.124.036611
Verkko-osoite: https://doi.org/10.1161/JAHA.124.036611
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/471044848
Background Atherosclerosis develops across the life course, and variation in aortic intima-media thickness (IMT) is evident from infancy onward, although most early-life data are cross-sectional. We investigated whether abdominal aortic IMT at age 6 weeks is associated with vascular measures at 4 years and the relationship of prenatal and perinatal exposures with these measures in early childhood.Methods and Results We analyzed data from 518 participants with 6-week and 4-year vascular measures from the Barwon Infant Study. Aortic IMT was measured at 6 weeks (mean, 6.1 +/- SD 1.5 weeks) and aortic and carotid IMT, carotid-femoral pulse wave velocity, and blood pressure at 4 years of age (4.3 +/- 0.3 years). Associations of early-life exposures-maternal enteric microbiome, smoking and low-density lipoprotein cholesterol during pregnancy, birth weight, and gestational age-were also investigated. In the primary model, 6-week aortic IMT (649 +/- 66 mu m) was associated with small differences in 4-year carotid IMT (453 +/- 45 mu m) (mean difference in carotid IMT per 100 mu m higher 6-week aortic IMT=7.0 mu m [95% CI, 0.7-13.3]; P=0.03), with no evidence for associations with 4-year aortic IMT, pulse wave velocity, or blood pressure. Higher birth weight was associated with greater 4-year aortic IMT, and maternal smoking with higher systolic blood pressure.Conclusions Vascular measures do not show strong evidence of tracking between infancy and early childhood. Longitudinal studies with repeated assessment beyond age 4 years would inform optimal timing of early prevention and targets for primordial prevention.
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Julkaisussa olevat rahoitustiedot:
The establishment work and infrastructure for the Barwon Infant Study was provided by the Murdoch Children's Research Institute, Deakin University, and Barwon Health. Subsequent funding was secured from the National Health and Medical Research Council of Australia, the Jack Brockhoff Foundation, the Scobie Trust, the Shane O'Brien Memorial Asthma Foundation, the Our Women's Our Children's Fund‐Raising Committee at Barwon Health, The Shepherd Foundation, the Rotary Club of Geelong, the Ilhan Food Allergy Foundation, GMHBA Limited, the Percy Baxter Charitable Trust managed by Perpetual Trustees, and the Minderoo Foundation. In‐kind support was provided by the Cotton On Foundation, and CreativeForce. Research at Murdoch Children's Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program. This work is also supported by project grants from the National Health and Medical Research Council of Australia (GTN1030701 and GTN1164212). Dr Nuotio is supported by Juho Vainio Foundation, Turku University Foundation, Yrjö Jahnsson Foundation, and Finnish Foundation for Cardiovascular Research. Dr Burgner is supported by an Investigator Grant from the National Health and Medical Research Council of Australia (GTN1175744). Dr Mansell is supported by an ECR Fellowship provided by the Murdoch Children's Research Institute. Dr Lawlor's contributions were supported by the British Heart Foundation (AA/18/1/34219 and CH/F/20/90003), the University of Bristol, and the UK Medical Research Council (MC_UU_00032/05). The funding bodies did not play any role in the study. The views expressed in this paper are those of the authors and not necessarily any funders or anyone acknowledged.
