Prevalence of Pertactin-Deficient Bordetella pertussis Isolates, Slovenia

: Barkoff, Alex-Mikael; Kastrin, Tamara; Seme, Katja; Vitek, Marta Grgič; Mertsola, Jussi; He, Qiushui

Publisher: Centers for Disease Control and Prevention (CDC)

: 2024

: Emerging Infectious Diseases

: 30

: 11

: 1080-6040

: 1080-6059

DOI: https://doi.org/10.3201/eid3011.231393

: http://doi.org/10.3201/eid3011.231393

: https://research.utu.fi/converis/portal/detail/Publication/470941132

In Slovenia, primary acellular pertussis vaccines (ACVs) containing pertactin (PRN) were mostly used during 1999-2016; ACVs without PRN were introduced in 2017. Among 123 Bordetella pertussis strains collected during 2002-2020, a total of 48 were PRN-deficient; 44 were collected after 2017. Changes to ACVs could increase PRN-deficient B. pertussis and infections.

23-1393.pdf

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This study is partly supported by Tampere Tuberculosis Foundation (grant no. 26006205), Sigrid Juselius Foundation (grant no. 240045), and EUpertstrain project (project nos. 26004877 and 26004878).