A1 Refereed original research article in a scientific journal
The benefits of a prolonged-release protein substitute with similarities to natural proteins as a treatment for phenylketonuria: a plain language summary of a study in healthy adults
Authors: MacDonald, Anita; Muntau, Ania C.; Scheinin, Mika; Costantino, Niko
Publisher: Informa UK Limited
Publication year: 2024
Journal: Future Rare Diseases
Journal name in source: Future Rare Diseases
Volume: 4
Issue: 1
eISSN: 2399-5270
DOI: https://doi.org/10.1080/23995270.2024.2411190
Web address : https://doi.org/10.1080/23995270.2024.2411190
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/470867318
What is this summary about?: This summary describes the results of a research study that investigated the benefits of a new protein substitute, a prolonged-release amino acid mixture, used to treat people with phenylketonuria. This new mixture was compared with a standard immediate-release amino acid mixture to examine amino acid absorption. The study included 35 healthy adults without phenylketonuria. What did the researchers find?: The peak amounts of amino acids in the blood were lower and the amino acids remained in the blood for longer after the prolonged-release mixture compared with the immediate-release mixture. The overall amounts of amino acids in the blood during the study were similar with both products. The difference between the amounts of nitrogen taken up and removed from the body (which is called the ‘nitrogen balance’), as well as the pattern of glucose and insulin levels in the blood, were better after the prolonged-release mixture. There were very few side effects when either of the amino acid mixtures was taken. What do the results of the study mean?: The prolonged-release and immediate-release amino acid mixtures did not differ in terms of the overall amounts of amino acids they released into the body, but they did differ in the benefits they provided, including a more natural pattern of amino acid absorption (similar to protein eaten from food), which results in the more effective use of amino acids by the body, with the prolonged-release mixture. Clinical Trial Registration: ISRCTN11016729 (ClinicalTrials.gov).
Downloadable publication This is an electronic reprint of the original article. |  |
Funding information in the publication:
The clinical trial upon which the current work is based was commissioned and funded by APR Applied Pharma Research S.A. (Balerna, Switzerland). The writing and publication of this summary was also funded by APR Applied Pharma Research S.A., Balerna, Switzerland.
