A1 Refereed original research article in a scientific journal
Ageing and cognition in men with fragile X syndrome
Authors: Oili Sauna-aho, Nina Bjelogrlic-Laakso, Päivi Rautava, Maria Arvio
Publisher: WILEY
Publication year: 2020
Journal: Journal of Applied Research in Intellectual Disabilities
Journal name in source: JOURNAL OF APPLIED RESEARCH IN INTELLECTUAL DISABILITIES
Journal acronym: J APPL RES INTELLECT
Number of pages: 6
ISSN: 1360-2322
eISSN: 1468-3148
DOI: https://doi.org/10.1111/jar.12733
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/47040508
Background Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability. The aim of our longitudinal study was to describe ageing-related cognitive changes in men with FXS.Method A neuropsychologist determined the raw scores (RSs) of 19 men with FXS twice with the Leiter International Performance Scale at an average interval of 22 years. The ages of the participants at baseline ranged from 16 to 50 (mean 27) years.Results At follow-up, the RSs improved in two men, remained the same in two men and declined in 15 men. Overall, the RS of the study group deteriorated by an average 4 points in RSs (p < .001).Conclusion Cognitive ageing in men with FXS started earlier than that in men in the general population; in many cases, cognitive ageing in men with FXS began before middle age, usually without any medical or other underlying cause.
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