Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1)

Enhanced new bone formation in canine maxilla by a graft of electrically polarized beta-tricalcium phosphate

Julkaisun tekijät: Nohara K, Itoh S, Akizuki T, Nakamura M, Fukuba S, Matsuura T, Okada M, Izumi Y, Iwata T, Yamashita K

Kustantaja: WILEY

Julkaisuvuosi: 2020

Journal: Journal of Biomedical Materials Research Part B: Applied Biomaterials


Lehden akronyymi: J BIOMED MATER RES B

Volyymi: 108

Julkaisunumero: 7

Sivujen määrä: 7

ISSN: 1552-4973

eISSN: 1552-4981


We succeeded in the electrical polarization of beta-tricalcium phosphate (beta-TCP) granules and performed an unprecedented attempt to implant them into maxillary bone defects in canines to confirm their ability to facilitate new bone formation. Two holes were drilled into each maxilla half of a canine and filled with electrically polarized and nonpolarized beta-TCP granules (grouping assignment was decided randomly). The implanted specimens were dissected en bloc and used for microcomputed tomography (mu CT) observations and histological analyses 4 and 8 weeks after the operation. New bone ingrowth in the bone hole progressed over time from the superficial layer of the cortex toward the inner cancellous bone. The percentage area of new bone in the bone hole, as measured by mu CT in the sagittal plane, was significantly larger after 4 and 8 weeks, and that measured by H&E-stained specimens in the transverse plane after 4 weeks was significantly larger in the polarized group than in the nonpolarized group. In addition to the structural stability and chemical characteristics of the beta-TCP granules, electrical stimulation bears influence not indirectly but directly on osteogenic and vessel cells, which might work cooperatively for the early initiation of the bone formation process.

Last updated on 2021-24-06 at 08:44