A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Reaction Times, Learning, and Executive Functioning in Adults Born Preterm

Julkaisun tekijät: Julia Suikkanen, Satu Miettola, Kati Heinonen, Marja Vääräsmäki, Marjaana Tikanmäki, Marika Sipola, Hanna-Maria Matinolli, Marjo-Riitta Järvelin, Katri Räikkönen, Petteri Hovi, Eero Kajantie

Julkaisuvuosi: 2020

Journal: Pediatric Research

Sivujen määrä: 7

ISSN: 0031-3998

DOI: http://dx.doi.org/10.1038/s41390-020-0851-4



This study examines cognitive functioning in adults born across
the range of prematurity with appropriate or small for gestational age
(SGA) birth weight compared with full-term controls.


ESTER Preterm Birth Study participants without severe
disabilities, comprising 133 early preterm (<34 weeks, 17% SGA), 241
late preterm (34 + 0-36 + 6 weeks, 13% SGA), and 348 full-term subjects,
performed the Cogstate® test at a mean age of 23.3 (SD = 1.2) years.
Subtests measured paired associate learning, psychomotor function,
executive function, spatial memory efficiency, visual memory, attention,
working memory, visual learning, and emotional cognition. Data were
analyzed with linear regression, full models adjusted for prenatal and
postnatal factors and socioeconomic position.


Early preterm, late preterm, and full-term participants showed
similar abilities in almost all subtests. Early preterm participants had
0.6 fewer moves/10 s (95% CI: -1.0; -0.2, full model) and late preterm
and SGA participants had 1.3 fewer moves/10 s (95% CI: -2.1; -0.4) than
full-term controls in the Groton Maze Learning Test, indicating weaker
spatial memory efficiency.


Adults born across the range of prematurity on average lack major
defects in cognitive abilities. Cognitive problems may persist to
adulthood only among those born the smallest: very preterm or preterm
and SGA.

Last updated on 2021-24-06 at 12:01