A2 Refereed review article in a scientific journal
Overall assessment of tumor-infiltrating lymphocytes in head and neck squamous cell carcinoma: time to take notice
Authors: Almangush A, Leivo I, Mäkitie AA
Publisher: TAYLOR & FRANCIS LTD
Publication year: 2020
Journal: Acta Oto-Laryngologica
Journal name in source: ACTA OTO-LARYNGOLOGICA
Journal acronym: ACTA OTO-LARYNGOL
Volume: 140
Issue: 3
First page : 246
Last page: 248
Number of pages: 3
ISSN: 0001-6489
DOI: https://doi.org/10.1080/00016489.2020.1720284
Self-archived copy’s web address: https://helda.helsinki.fi/bitstream/10138/337014/1/Ma_kitie_et_al_Acta_Otolaryngol_2020.pdf
Abstract
Background: The immune response has an important role in cancer progression. At the same time, anti-tumor effect of the immune response has been speculated to cause destruction of cancer cells. Recent studies have highlighted the significance of tumor-infiltrating lymphocytes (TILs) in different cancers. The International Immuno-Oncology Biomarkers Working Group has in 2017 published a practical review proposing a standardized method to assess TILs in the routine hematoxylin and eosin (HE) stained sections. Aims/objectives: To discuss the association between TILs and survival in head and neck squamous cell carcinoma (HNSCC). Material and methods: We review recent studies having assessed TILs in HNSCC and showing that tumors having low TILs associate significantly with worse survival. Results: These findings underline that HNSCC cases with low TILs might benefit from multimodality treatment and might be indicated to receive immunotherapy. Conclusions: The evaluation of TILs using routine HE-stained sections is practical and can be considered in assessment of antitumor activity.
Background: The immune response has an important role in cancer progression. At the same time, anti-tumor effect of the immune response has been speculated to cause destruction of cancer cells. Recent studies have highlighted the significance of tumor-infiltrating lymphocytes (TILs) in different cancers. The International Immuno-Oncology Biomarkers Working Group has in 2017 published a practical review proposing a standardized method to assess TILs in the routine hematoxylin and eosin (HE) stained sections. Aims/objectives: To discuss the association between TILs and survival in head and neck squamous cell carcinoma (HNSCC). Material and methods: We review recent studies having assessed TILs in HNSCC and showing that tumors having low TILs associate significantly with worse survival. Results: These findings underline that HNSCC cases with low TILs might benefit from multimodality treatment and might be indicated to receive immunotherapy. Conclusions: The evaluation of TILs using routine HE-stained sections is practical and can be considered in assessment of antitumor activity.
UTU Research Portal